Abstract
A group of indolyl-benzimidazolone-piperidines is described and the structure-activity with reference to the passive cutaneous anaphylaxis (PCA) in rats is discussed. Compound 7b, 4-(indolyl-3)-1-(benzimidazolonyl-propyl)-piperidine, which has the highest potency in this test, was studied in more detail with regard to antihistaminic and secretory cell stabilization properties.
MeSH terms
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Animals
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Basophils / metabolism
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Benzimidazoles / chemical synthesis*
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Benzimidazoles / pharmacology
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Guinea Pigs
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Histamine H1 Antagonists / chemical synthesis*
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Histamine Release / drug effects
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Humans
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In Vitro Techniques
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Male
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Mast Cells / drug effects
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Muscle Contraction / drug effects
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Muscle, Smooth / drug effects
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Passive Cutaneous Anaphylaxis / drug effects
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Peritoneal Cavity / cytology
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Piperidines / chemical synthesis*
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Piperidines / pharmacology
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Rats
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Rats, Inbred Strains
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Structure-Activity Relationship
Substances
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Benzimidazoles
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Histamine H1 Antagonists
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Piperidines