RIFM fragrance ingredient safety assessment, α-Irone, CAS registry number 79-69-6

A M Api; D Belsito; S Bhatia; M Bruze; P Calow; M L Dagli; W Dekant; A D Fryer; L Kromidas; S La Cava; J F Lalko; A Lapczynski; D C Liebler; Y Miyachi; V T Politano; G Ritacco; D Salvito; J Shen; T W Schultz; I G Sipes; B Wall; D K Wilcox

doi:10.1016/j.fct.2015.03.019

RIFM fragrance ingredient safety assessment, α-Irone, CAS registry number 79-69-6

Food Chem Toxicol. 2015 Aug:82 Suppl:S105-13. doi: 10.1016/j.fct.2015.03.019. Epub 2015 Mar 27.

Authors

A M Api¹, D Belsito², S Bhatia¹, M Bruze³, P Calow⁴, M L Dagli⁵, W Dekant⁶, A D Fryer⁷, L Kromidas⁸, S La Cava¹, J F Lalko¹, A Lapczynski¹, D C Liebler⁹, Y Miyachi¹⁰, V T Politano¹, G Ritacco¹, D Salvito¹, J Shen¹, T W Schultz¹¹, I G Sipes¹², B Wall¹, D K Wilcox¹

Affiliations

¹ Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
² Member RIFM Expert Panel, Columbia University Medical Center, Department of Dermatology, 161 Fort Washington Ave., New York, NY 10032, USA.
³ Department of Occupational & Environmental Dermatology, Member RIFM Expert Panel, Malmo University Hospital, Sodra Forstadsgatan 101, Entrance 47, Malmo SE-20502, Sweden.
⁴ Member RIFM Expert Panel, University of Nebraska Lincoln, 230 Whittier Research Center, Lincoln, NE 68583-0857, USA.
⁵ Department of Pathology, School of Veterinary Medicine and Animal Science, Member RIFM Expert Panel, University of Sao Paulo, Av. Prof. dr. Orlando Marques de Paiva, 87, Sao Paulo, CEP 05508-900, Brazil.
⁶ Department of Toxicology, Member RIFM Expert Panel, University of Wuerzburg, Versbacher Str. 9, Würzburg 97078, Germany.
⁷ Member RIFM Expert Panel, Oregon Health Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239, USA.
⁸ Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA. Electronic address: [email protected].
⁹ Member RIFM Expert Panel, Vanderbilt University School of Medicine, Department of Biochemistry, Center in Molecular Toxicology, 638 Robinson Research Building, 2200 Pierce Avenue, Nashville, TN 37232-0146, USA.
¹⁰ Member RIFM Expert Panel, Department of Dermatology, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
¹¹ Department of Comparative Medicine, Member RIFM Expert Panel, The University of Tennessee, College of Veterinary Medicine, 2407 River Dr., Knoxville, TN 37996-4500, USA.
¹² Member RIFM Expert Panel, Department of Pharmacology, University of Arizona, College of Medicine, 1501 North Campbell Avenue, P.O. Box 245050, Tucson, AZ 85724-5050, USA.

PMID: 25817021
DOI: 10.1016/j.fct.2015.03.019

No abstract available

MeSH terms

Animals
Consumer Product Safety*
DNA Damage / drug effects
Dose-Response Relationship, Drug
Endpoint Determination
Female
Humans
Male
Mice
No-Observed-Adverse-Effect Level
Norisoprenoids / chemistry
Norisoprenoids / toxicity*
Perfume / chemistry
Perfume / toxicity*
Rats
Risk Assessment
Toxicity Tests

Substances

Norisoprenoids
Perfume
alpha-irone