Placental deposition of C-reactive protein is a common feature of human pregnancy

E N Kim; B H Yoon; E J Jeon; J B Lee; J-S Hong; J Y Lee; D Hwang; K C Kim; J-S Kim; C J Kim

doi:10.1016/j.placenta.2015.03.006

Placental deposition of C-reactive protein is a common feature of human pregnancy

Placenta. 2015 Jun;36(6):704-7. doi: 10.1016/j.placenta.2015.03.006. Epub 2015 Mar 17.

Authors

E N Kim¹, B H Yoon², E J Jeon³, J B Lee⁴, J-S Hong⁵, J Y Lee⁶, D Hwang⁶, K C Kim⁶, J-S Kim⁷, C J Kim⁸

Affiliations

¹ Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea; Asan Laboratory of Perinatal Science, Asan Medical Center, Seoul, Republic of Korea.
² Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea.
³ Asan Laboratory of Perinatal Science, Asan Medical Center, Seoul, Republic of Korea.
⁴ Department of Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
⁵ Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea.
⁶ Hamchoon Women's Clinic, Seoul, Republic of Korea.
⁷ Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
⁸ Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea; Asan Laboratory of Perinatal Science, Asan Medical Center, Seoul, Republic of Korea. Electronic address: [email protected].

PMID: 25817719
DOI: 10.1016/j.placenta.2015.03.006

Abstract

This study examined the occurrence of placental C-reactive protein (CRP) in normal pregnancy with term delivery, spontaneous preterm delivery (sPTD), preeclampsia, and miscarriage. CRP immunoreactivity was detected in the syncytiotrophoblast. The immunopositive rate was significantly higher in sPTD than preeclampsia. The CRP immunopositive rate was also higher in acute chorioamnionitis than those without and showed a good correlation with the maternal serum CRP concentration. CRP mRNA expression was not detected in human and mouse placentas or choriocarcinoma cells. CRP may play a role in the pathological and physiological states of pregnancy.

Keywords: C-reactive protein; Immunohistochemistry; Placenta; Trophoblast.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Abortion, Spontaneous / metabolism
Animals
C-Reactive Protein / metabolism*
Female
Humans
Mice
Obstetric Labor, Premature / metabolism
Placenta / metabolism*
Pre-Eclampsia / metabolism
Pregnancy
Trophoblasts / metabolism*

Substances

C-Reactive Protein