Cytidine-stabilized gold nanocluster as a fluorescence turn-on and turn-off probe for dual functional detection of Ag(+) and Hg(2+)

Anal Chim Acta. 2015 Apr 22:870:1-7. doi: 10.1016/j.aca.2015.01.016. Epub 2015 Jan 14.

Abstract

In this study, we have developed a label-free, dual functional detection strategy for highly selective and sensitive determination of aqueous Ag(+) and Hg(2+) by using cytidine stabilized Au NCs and AuAg NCs as fluorescent turn-on and turn off probes, respectively. The Au NCs and AuAg NCs showed a remarkably rapid response and high selectivity for Ag(+) and Hg(2+) over other metal ions, and relevant detection limit of Ag(+) and Hg(2+) is ca. 10 nM and 30 nM, respectively. Importantly, the fluorescence enhanced Au NCs by doping Ag(+) can be conveniently reusable for the detection of Hg(2+) based on the corresponding fluorescence quenching. The sensing mechanism was based on the high-affinity metallophilic Hg(2+)-Ag(+) interaction, which effectively quenched the fluorescence of AuAg NCs. Furthermore, these fluorescent nanoprobes could be readily applied to Ag(+) and Hg(2+) detection in environmental water samples, indicating their possibility to be utilized as a convenient, dual functional, rapid response, and label-free fluorescence sensor for related environmental and health monitoring.

Keywords: Fluorescence; Gold nanocluster; Lake water; Mercury ion; Reusable sensor; Silver ion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cytidine / chemistry*
  • Fluorescent Dyes / chemistry*
  • Gold / chemistry*
  • Lakes / chemistry
  • Limit of Detection
  • Mercury / analysis*
  • Mercury / chemistry
  • Models, Molecular
  • Molecular Conformation
  • Nanoparticles / chemistry*
  • Rivers / chemistry
  • Silver / analysis*
  • Silver / chemistry
  • Spectrometry, Fluorescence

Substances

  • Fluorescent Dyes
  • Silver
  • Cytidine
  • Gold
  • Mercury