Stereotactic body radiotherapy for oligometastases confined to the para-aortic region: clinical outcomes and the significance of radiotherapy field and dose

Cancer Invest. 2015 May;33(5):180-7. doi: 10.3109/07357907.2015.1019678. Epub 2015 Apr 1.

Abstract

We retrospectively reviewed 88 patients with oligometases in the para-aortic region from any controlled primary tumor site who were treated with stereotactic body radiotherapy (SBRT). The 5-year local control, disease-free survival, and overall survival rates were 83%, 31%, and 41%, respectively. A 90% tumor-control probability was predicted at a biological effective dose of 90 Gy. Severe gastrointestinal toxicities (grade ≥3) were observed in 2 of 88 patients (1%). The results of this study are limited by the retrospective nature of the study but could serve as the background and rationale for future prospective trials on SBRT-based treatment for oligometastses.

Keywords: Outcomes research; Prognosis and response predictions; Radiation oncology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Disease-Free Survival
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Neoplasms / pathology
  • Neoplasms / radiotherapy*
  • Neoplasms / surgery
  • Prognosis*
  • Radiosurgery*
  • Retrospective Studies
  • Survival Rate
  • Treatment Outcome