Evaluation of cases with a preliminary diagnosis of Crimean- Congo hemorrhagic fever and comparison of characteristics in patients admitted to a secondary care hospital in Kastamonu, Turkey

Afr Health Sci. 2014 Dec;14(4):873-81. doi: 10.4314/ahs.v14i4.15.

Abstract

Background: Crimean-Congo hemorrhagic fever (CCHF) is an endemic disease in Turkey. The clinical presentation and laboratory findings are not specific especially in cases without hemorrhagic findings.

Objective: We aimed to evaluate CCHF cases and compare them with non-CCHF cases in terms of their characteristics during admission.

Methods: Cases with a preliminary diagnosis of CCHF at a secondary care hospital in Kastamonu in 2013 were evaluated, retrospectively. Cases testing RNA/IgM positive were considered as CCHF. Cases testing both RNA and IgM negative were considered as non-CCHF. The two groups were then compared in terms of their clinical, laboratory and epidemiological characteristics during admission.

Results: A total of 41 cases were tested and CCHF was found in 46.3% of cases. Fatality was 5.3% in CCHF cases. The frequency of tick bites and CK elevation in CCHF cases was significantly higher than non-CCHF cases (p<0.05). There were no significant differences between the two groups regarding other characteristics (p>0.05).

Conclusions: In cases with a preliminary diagnosis of CCHF, especially in cases without a history of tick bite and with normal CK levels during admission, performing tests for the differential diagnosis may be advisable without waiting for the results of tests for CCHF.

Keywords: Crimean-congo hemorrhagic fever; Kastamonu; Turkey.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antibodies, Viral / blood*
  • Child
  • Child, Preschool
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Hemorrhagic Fever Virus, Crimean-Congo / genetics
  • Hemorrhagic Fever Virus, Crimean-Congo / immunology
  • Hemorrhagic Fever Virus, Crimean-Congo / isolation & purification*
  • Hemorrhagic Fever, Crimean / diagnosis*
  • Hemorrhagic Fever, Crimean / drug therapy
  • Hemorrhagic Fever, Crimean / mortality
  • Humans
  • Immunoglobulin M / analysis
  • Incidence
  • Male
  • Middle Aged
  • RNA, Viral / analysis
  • Retrospective Studies
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sex Distribution
  • Survival Rate
  • Turkey / epidemiology
  • Young Adult

Substances

  • Antibodies, Viral
  • Immunoglobulin M
  • RNA, Viral