Enantioselective Arylative Dearomatization of Indoles via Pd-Catalyzed Intramolecular Reductive Heck Reactions

J Am Chem Soc. 2015 Apr 22;137(15):4936-9. doi: 10.1021/jacs.5b01705. Epub 2015 Apr 10.

Abstract

A highly enantioselective intramolecular arylative dearomatization of indoles via palladium-catalyzed reductive Heck reactions was developed. The new strategy led to a series of optically active indolines bearing C2-quaternary stereocenters in modest to good yields with excellent enantioselectivities (up to 99% ee).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Cyclization
  • Indoles / chemical synthesis
  • Indoles / chemistry*
  • Molecular Structure
  • Organometallic Compounds / chemistry*
  • Palladium / chemistry*
  • Stereoisomerism

Substances

  • Indoles
  • Organometallic Compounds
  • Palladium
  • indoline