Investigating influenza A virus infection: tools to track infection and limit tropism

Jessica K Fiege; Ryan A Langlois

doi:10.1128/JVI.00462-15

Investigating influenza A virus infection: tools to track infection and limit tropism

J Virol. 2015 Jun;89(12):6167-70. doi: 10.1128/JVI.00462-15. Epub 2015 Apr 8.

Authors

Jessica K Fiege¹, Ryan A Langlois²

Affiliations

¹ Department of Microbiology and Immunology and Center for Immunology, University of Minnesota, Minneapolis, Minnesota, USA.
² Department of Microbiology and Immunology and Center for Immunology, University of Minnesota, Minneapolis, Minnesota, USA [email protected].

Abstract

Influenza A viruses display a broad cellular tropism within the respiratory tracts of mammalian hosts. Uncovering the relationship between tropism and virus immunity, pathogenesis, and transmission will be critical for the development of therapeutic interventions. Here we discuss recent developments of several recombinant strains of influenza A virus. These viruses have inserted reporters to track tropism, microRNA target sites to restrict tropism, or barcodes to assess transmission dynamics, expanding our understanding of pathogen-host interactions.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Genes, Reporter
Host-Pathogen Interactions*
Humans
Influenza A virus / genetics*
Influenza A virus / physiology*
Molecular Biology / methods*
Viral Tropism*
Virology / methods*

Grants and funding

T32 HL007741/HL/NHLBI NIH HHS/United States