(111)In-octreotide SPECT-CT in head and neck paragangliomas

C Castillo-Berrio; M Castrillón; F Zelaya; D Ruíz; F Loira; J M Nogueiras; A López; R Guitián; J Outomuro; A Serena; L M Campos

doi:10.1016/j.remn.2015.02.007

(111)In-octreotide SPECT-CT in head and neck paragangliomas

Rev Esp Med Nucl Imagen Mol. 2015 Sep-Oct;34(5):321-4. doi: 10.1016/j.remn.2015.02.007. Epub 2015 Apr 6.

[Article in English, Spanish]

Authors

C Castillo-Berrio¹, M Castrillón², F Zelaya², D Ruíz², F Loira², J M Nogueiras², A López², R Guitián², J Outomuro², A Serena², L M Campos²

Affiliations

¹ Servicio de Medicina Nuclear, Hospital Meixoeiro, Vigo, Pontevedra, España. Electronic address: [email protected].
² Servicio de Medicina Nuclear, Hospital Meixoeiro, Vigo, Pontevedra, España.

PMID: 25858499
DOI: 10.1016/j.remn.2015.02.007

Abstract

Head and neck paragangliomas are rare neuroendocrine tumors expressing somatostatin receptors on their cell surface, particularly subtype 2. Due to this distinctive feature, images can be obtained in Nuclear Medicine using synthetic analogues of somatostatin, mainly octreotide, which allow selective display by planar scintigraphy, SPECT-CT or PET-CT imaging after radiolabeling with (111)In or (68)Ga. Three cases have been selected and presented from a series of patients that illustrate the utility of SPECT-CT studies with (111)In-octreotide in the diagnosis and monitoring of this type of tumor. These are characterization at initial diagnosis, staging, and detection of local recurrence or metastasis, with added value with respect to anatomical images (nuclear magnetic resonance, computed axial tomography, angiography), for example in the differentiation between functional tissue or scar in patients who had previously undergone surgery.

Keywords: (111)In-octreotide; Gammagrafía; Paraganglioma; SPECT-CT; SPECT-TC; Scintigraphy; Somatostatin; Somatostatina.

Publication types

Case Reports

MeSH terms

Carotid Body Tumor / diagnostic imaging
Carotid Body Tumor / surgery
Cicatrix / diagnosis
Diagnosis, Differential
Female
Glomus Tympanicum Tumor / chemistry
Glomus Tympanicum Tumor / diagnostic imaging
Glomus Tympanicum Tumor / surgery
Head and Neck Neoplasms / chemistry
Head and Neck Neoplasms / diagnostic imaging*
Head and Neck Neoplasms / surgery
Humans
Indium Radioisotopes
Lymphatic Metastasis / diagnostic imaging
Male
Middle Aged
Neoplasm Recurrence, Local / diagnosis
Neoplasm, Residual
Octreotide / analogs & derivatives
Paraganglioma, Extra-Adrenal / chemistry
Paraganglioma, Extra-Adrenal / diagnostic imaging*
Paraganglioma, Extra-Adrenal / secondary
Paraganglioma, Extra-Adrenal / surgery
Postoperative Complications / diagnosis
Radiopharmaceuticals
Receptors, Somatostatin / analysis
Single Photon Emission Computed Tomography Computed Tomography*

Substances

Indium Radioisotopes
Radiopharmaceuticals
Receptors, Somatostatin
indium-111-octreotide
Octreotide