Model-based acceleration of look-locker T1 mapping

PLoS One. 2015 Apr 10;10(4):e0122611. doi: 10.1371/journal.pone.0122611. eCollection 2015.

Abstract

Mapping the longitudinal relaxation time T1 has widespread applications in clinical MRI as it promises a quantitative comparison of tissue properties across subjects and scanners. Due to the long scan times of conventional methods, however, the use of quantitative MRI in clinical routine is still very limited. In this work, an acceleration of Inversion-Recovery Look-Locker (IR-LL) T1 mapping is presented. A model-based algorithm is used to iteratively enforce an exponential relaxation model to a highly undersampled radially acquired IR-LL dataset obtained after the application of a single global inversion pulse. Using the proposed technique, a T1 map of a single slice with 1.6mm in-plane resolution and 4mm slice thickness can be reconstructed from data acquired in only 6s. A time-consuming segmented IR experiment was used as gold standard for T1 mapping in this work. In the subsequent validation study, the model-based reconstruction of a single-inversion IR-LL dataset exhibited a T1 difference of less than 2.6% compared to the segmented IR-LL reference in a phantom consisting of vials with T1 values between 200ms and 3000ms. In vivo, the T1 difference was smaller than 5.5% in WM and GM of seven healthy volunteers. Additionally, the T1 values are comparable to standard literature values. Despite the high acceleration, all model-based reconstructions were of a visual quality comparable to fully sampled references. Finally, the reproducibility of the T1 mapping method was demonstrated in repeated acquisitions. In conclusion, the presented approach represents a promising way for fast and accurate T1 mapping using radial IR-LL acquisitions without the need of any segmentation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Algorithms
  • Brain / diagnostic imaging*
  • Humans
  • Magnetic Resonance Imaging* / instrumentation
  • Magnetic Resonance Imaging* / methods
  • Models, Theoretical*
  • Phantoms, Imaging
  • Radiography
  • Reproducibility of Results

Grants and funding

JT-G was supported by a grant of the German Excellence Initiative to the Graduate School of Life Sciences, University of Würzburg. Also, the costs for the open access publication itself will be borne by the German Research Foundation (DFG) and the University of Würzburg in the funding programme Open Access Publishing. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.