IL-33 impacts on the skin barrier by downregulating the expression of filaggrin

J Allergy Clin Immunol. 2015 Jun;135(6):1659-61.e4. doi: 10.1016/j.jaci.2015.01.048. Epub 2015 Apr 9.
No abstract available

Publication types

  • Letter

MeSH terms

  • 2S Albumins, Plant / immunology
  • 2S Albumins, Plant / pharmacology
  • Antigens, Plant / immunology
  • Antigens, Plant / pharmacology
  • Biopsy
  • Calcium / metabolism
  • Case-Control Studies
  • Cell Differentiation / drug effects
  • Dermatitis, Atopic / genetics*
  • Dermatitis, Atopic / immunology
  • Dermatitis, Atopic / metabolism
  • Dermatitis, Atopic / pathology
  • Filaggrin Proteins
  • Gene Expression Regulation
  • Glycoproteins / immunology
  • Glycoproteins / pharmacology
  • Humans
  • Interleukin-33
  • Interleukin-4 / immunology
  • Interleukin-4 / metabolism
  • Interleukin-4 / pharmacology*
  • Interleukins / immunology
  • Interleukins / metabolism
  • Interleukins / pharmacology*
  • Intermediate Filament Proteins / antagonists & inhibitors*
  • Intermediate Filament Proteins / genetics
  • Intermediate Filament Proteins / immunology
  • Keratinocytes / drug effects*
  • Keratinocytes / immunology
  • Keratinocytes / pathology
  • Permeability / drug effects
  • Primary Cell Culture
  • Skin / drug effects*
  • Skin / immunology
  • Skin / pathology

Substances

  • 2S Albumins, Plant
  • Antigens, Plant
  • Ara h 2 allergen, Arachis hypogaea
  • FLG protein, human
  • Filaggrin Proteins
  • Glycoproteins
  • IL33 protein, human
  • IL4 protein, human
  • Interleukin-33
  • Interleukins
  • Intermediate Filament Proteins
  • Interleukin-4
  • Calcium