Abstract
An amine-reactive fluorogenic molecule specifically turned on by superoxide radicals (O2˙(-)) was synthesized and coupled to a mitochondrial (MT) targeting peptide. The obtained probe showed superior uptake and MT targeting capabilities; and successfully detected the change in O2˙(-) levels in cells treated with chemical stimuli or single-walled carbon nanotubes.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
-
Amines / chemical synthesis
-
Amines / chemistry*
-
Animals
-
Cell Line
-
Fluorescent Dyes / analysis
-
Fluorescent Dyes / chemical synthesis
-
Fluorescent Dyes / chemistry
-
Fluorescent Dyes / metabolism*
-
Macrophages / cytology
-
Macrophages / drug effects
-
Macrophages / metabolism
-
Mice
-
Mitochondria / metabolism*
-
Molecular Structure
-
Nanotubes, Carbon / chemistry
-
Superoxides / analysis*
-
Superoxides / chemistry
Substances
-
Amines
-
Fluorescent Dyes
-
Nanotubes, Carbon
-
Superoxides