Abstract
Peptide aptamers are small combinatorial proteins that are selected to bind to specific sites on their target molecules. Peptide aptamers consist of short, 5-20 amino acid residues long sequences, typically embedded as a loop within a stable protein scaffold. Various peptide aptamer scaffolds and in vitro and in vivo selection techniques are reviewed with emphasis on specific biomedical, bioimaging, and bioanalytical applications.
Publication types
-
Research Support, N.I.H., Extramural
-
Review
MeSH terms
-
Antibodies / chemistry
-
Aptamers, Peptide / chemistry*
-
Aptamers, Peptide / pharmacology
-
Armadillo Domain Proteins / chemistry
-
Directed Molecular Evolution / methods*
-
Gene Expression Profiling / methods
-
Humans
-
Models, Molecular
-
Molecular Imaging / methods
-
Peptide Library*
-
Protein Structure, Secondary
-
Protein Structure, Tertiary
-
SELEX Aptamer Technique / methods*
-
Two-Hybrid System Techniques
Substances
-
Antibodies
-
Aptamers, Peptide
-
Armadillo Domain Proteins
-
Peptide Library