Ten flavonoid glycosides, apetalumosides A (1), B1-B7 (2-8), and C (9), quercetin 3-O-(2,6-di-O-β-D-glucopyranosyl)-β-D-glucopyranoside (10), were obtained from the seeds of Lepidium apetalum Willd. Their structures were elucidated by chemical and spectroscopic methods (UV, IR, NMR, and HRESI-TOF-MS). 1-9 were new isolates. The NMR data for 10 was reported here for the first time. On the other hand, activity screening results showed that 1-3 and 10 had triglyceride accumulation inhibitory effects in HepG2 cells. Preliminary structure-activity relationship study revealed that 7-hydroxyl group is an essential moiety.
Keywords: Flavonoid glycosides; HepG2 cells; Lepidium apetalum; Triglyceride accumulation inhibitory effects.
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