Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma

Affiliations

• ¹ Department of Molecular Biotechnology and Health Science and Center for Experimental Research and Medical Studies, University of Torino, 10126 Torino, Italy; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA.
• ² Department of Molecular Biotechnology and Health Science and Center for Experimental Research and Medical Studies, University of Torino, 10126 Torino, Italy; Department of Control and Computer Engineering, Politecnico di Torino, 10129 Torino, Italy; Department of Biomedical Informatics and Department of Systems Biology, Center for Computational Biology and Bioinformatics, Columbia University, New York, NY 10027, USA.
• ³ Department of Molecular Biotechnology and Health Science and Center for Experimental Research and Medical Studies, University of Torino, 10126 Torino, Italy.
• ⁴ Department of Control and Computer Engineering, Politecnico di Torino, 10129 Torino, Italy.
• ⁵ Department of Pathology, A.O. Città della Salute e della Scienza (Molinette), 10126 Torino, Italy.
• ⁶ Lymphoma and Genomics Research Program, Institute of Oncology Research, 6500 Bellinzona, Switzerland.
• ⁷ Translational Cell and Tissue Research Lab, KU Leuven, 3000 Leuven, Belgium.
• ⁸ Institute of Pathology, University of Würzburg and Comprehensive Cancer Center Mainfranken, 97080 Würzburg, Germany.
• ⁹ Ludwing Boltzmann Institute for Cancer Research, 1090 Vienna, Austria.
• ¹⁰ Research Unit Dermatopathology of the Medical University of Graz, 8036 Graz, Austria.
• ¹¹ Institute of Pathology, University Hospital Basel, 4031 Basel, Switzerland.
• ¹² Pathology & Lymphoid Malignancies Units, San Raffaele Scientific Institute, 20132 Milan, Italy.
• ¹³ Department of Human Pathology, University of Pavia and Scientific Institute Fondazione Policlinico San Matteo, 27100 Pavia, Italy.
• ¹⁴ Department of Pathology, City of Hope Medical Center, Duarte, CA 91010, USA.
• ¹⁵ Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
• ¹⁶ Cancer Genomics, Instituto de Formación e Investigación Marqués de Valdecilla and Department of Pathology, Hospital Universitario Marqués de Valdecilla, 39008 Santander, Spain.
• ¹⁷ Department of Pathology and Diagnostics, University of Verona, 37134 Verona, Italy.
• ¹⁸ Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, 28100 Novara, Italy.
• ¹⁹ European Institute of Oncology, 20141 Milano, Italy; Bologna University School of Medicine, 40126 Bologna, Italy.
• ²⁰ Institute of Hematology-Centro di Ricerche Onco-Ematologiche (CREO), Ospedale S. Maria della Misericordia, University of Perugia, 06100 Perugia, Italy.
• ²¹ The Jackson Laboratory, Bar Harbor, ME 04609, USA.
• ²² Janssen Research & Development, a Division of Janssen-Cilag, Campus de Maigremont, CS10615, 27106 Val-de-Reuil Cedex, France.
• ²³ Janssen Research & Development, a Division of Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium.
• ²⁴ Department of Molecular Biotechnology and Health Science and Center for Experimental Research and Medical Studies, University of Torino, 10126 Torino, Italy; Department of Pathology and NYU Cancer Center, New York University School of Medicine, New York, NY 10016, USA.
• ²⁵ Lymphoma and Genomics Research Program, Institute of Oncology Research, 6500 Bellinzona, Switzerland; Oncology Institute of Southern Switzerland, 6500 Bellinzona, Switzerland.
• ²⁶ Department of Biomedical Informatics and Department of Systems Biology, Center for Computational Biology and Bioinformatics, Columbia University, New York, NY 10027, USA. Electronic address: [email protected].
• ²⁷ Department of Molecular Biotechnology and Health Science and Center for Experimental Research and Medical Studies, University of Torino, 10126 Torino, Italy; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA; Department of Pathology and NYU Cancer Center, New York University School of Medicine, New York, NY 10016, USA. Electronic address: [email protected].