Direct conversion of allyl arenes to aryl ethylketones via a TBHP-mediated palladium-catalyzed tandem isomerization-Wacker oxidation of terminal alkenes

Org Biomol Chem. 2015 May 28;13(20):5613-6. doi: 10.1039/c5ob00586h. Epub 2015 Apr 17.

Abstract

A TBHP-mediated palladium-catalyzed tandem isomerization-Wacker oxidation of terminal alkenes was developed. This methodology provides a new efficient and simple route for conversion of a range of allyl arenes directly into aryl ethylketones in good yields with high chemoselectivity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry*
  • Allyl Compounds / chemistry*
  • Catalysis
  • Ketones / chemistry*
  • Molecular Structure
  • Oxidation-Reduction
  • Palladium / chemistry*
  • Stereoisomerism
  • tert-Butylhydroperoxide / chemistry*

Substances

  • Alkenes
  • Allyl Compounds
  • Ketones
  • Palladium
  • tert-Butylhydroperoxide