Unnatural agrochemical ligands for engineered abscisic acid receptors

Trends Plant Sci. 2015 Jun;20(6):330-2. doi: 10.1016/j.tplants.2015.04.001. Epub 2015 Apr 16.

Abstract

Existing agrochemicals can be endowed with new applications through protein engineering of plant receptors. A recent study shows an engineered PYR1 ABA receptor can be activated by mandipropamid. Plants engineered with such PYR1 variant are responsive to this agrochemical, which confers protection against drought through activation of ABA signaling.

Keywords: agrochemical; engineered ABA receptor; orthogonal ligand-receptor; unnatural ligand.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Abscisic Acid / metabolism*
  • Agrochemicals / pharmacology*
  • Amides / pharmacology*
  • Arabidopsis Proteins / genetics*
  • Arabidopsis Proteins / metabolism*
  • Carboxylic Acids / pharmacology*
  • Membrane Transport Proteins / genetics*
  • Membrane Transport Proteins / metabolism*
  • Plants / drug effects*
  • Plants / metabolism*
  • Water / metabolism*

Substances

  • Agrochemicals
  • Amides
  • Arabidopsis Proteins
  • Carboxylic Acids
  • Membrane Transport Proteins
  • Water
  • Abscisic Acid