Response to cytochrome P450-derived versus mitochondrial oxidant stress in acetaminophen hepatotoxicity

Toxicol Lett. 2015 Jun 15;235(3):218-9. doi: 10.1016/j.toxlet.2015.04.003. Epub 2015 Apr 17.

Authors

Jian Jiang¹, Jacob J Briedé², Danyel G J Jennen², Jos C S Kleinjans², Theo M C M de Kok²

Affiliations

¹ Department of Toxicogenomics, School of Oncology and Developmental Biology (GROW), Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands. Electronic address: [email protected].
² Department of Toxicogenomics, School of Oncology and Developmental Biology (GROW), Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

PMID: 25895633
DOI: 10.1016/j.toxlet.2015.04.003

No abstract available

Publication types

Letter
Comment

MeSH terms

Acetaminophen / toxicity*
Chemical and Drug Induced Liver Injury / etiology*
Electron Transport Chain Complex Proteins / metabolism*
Hepatocytes / drug effects*
Humans
Mitochondria, Liver / drug effects*
Oxidative Stress / drug effects*
Reactive Oxygen Species / metabolism*

Substances

Electron Transport Chain Complex Proteins
Reactive Oxygen Species
Acetaminophen