Smart soft-templating synthesis of hollow mesoporous bioactive glass spheres

Chemistry. 2015 May 26;21(22):8038-42. doi: 10.1002/chem.201406570. Epub 2015 Apr 20.

Abstract

Hollow bioactive glass spheres with mesoporous shells were prepared by using dual soft templates, a diblock co-polymer poly(styrene-b-acrylic acid) (PS-b-PAA) and a cationic surfactant cetyltrimethylammonium bromide (CTAB). Hollow mesoporous bioactive glass (HMBG) spheres comprise the large hollow interior with vertical mesochannels in shell, which realize large uptake of drugs and their sustained release. The formation of hydroxyapatite layer on the surface of HMBG particles shows the clear evidence for promising application in bone regeneration.

Keywords: bioactive glass; hollow spheres; mesoporous materials; polymeric micelles; surfactants.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylates / chemical synthesis
  • Acrylates / chemistry*
  • Ceramics / chemical synthesis*
  • Ceramics / chemistry
  • Cetrimonium
  • Cetrimonium Compounds / chemistry*
  • Coated Materials, Biocompatible / chemical synthesis
  • Coated Materials, Biocompatible / chemistry
  • Delayed-Action Preparations / chemical synthesis*
  • Delayed-Action Preparations / chemistry
  • Durapatite / chemical synthesis
  • Durapatite / chemistry
  • Particle Size
  • Polystyrenes / chemical synthesis
  • Polystyrenes / chemistry*
  • Porosity
  • Surface-Active Agents / chemistry*

Substances

  • Acrylates
  • Bioglass
  • Cetrimonium Compounds
  • Coated Materials, Biocompatible
  • Delayed-Action Preparations
  • Polystyrenes
  • Surface-Active Agents
  • poly(styrene-b-acrylic acid)
  • Durapatite
  • Cetrimonium