Human Invasive Muscular Sarcocystosis Induces Th2 Cytokine Polarization and Biphasic Cytokine Changes, Based on an Investigation among Travelers Returning from Tioman Island, Malaysia

Clin Vaccine Immunol. 2015 Jun;22(6):674-7. doi: 10.1128/CVI.00042-15. Epub 2015 Apr 22.

Abstract

Sarcocystis nesbitti is a parasite responsible for a biphasic eosinophilic febrile myositis syndrome in two recent outbreaks in Malaysia. We demonstrate Th2 cytokine polarization in infected travelers, an overall cytokine production decrease in the early phase of the disease suggestive of initial immunosuppression, and elevated levels of proinflammatory and chemotactic cytokines in the later myositic phase.

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Cytokines / blood*
  • Female
  • Humans
  • Immune Tolerance
  • Malaysia
  • Male
  • Sarcocystis / immunology*
  • Sarcocystosis / immunology
  • Sarcocystosis / pathology*
  • Th2 Cells / immunology
  • Travel
  • Young Adult

Substances

  • Cytokines