Genetic variants in interleukin 7 receptor α chain (IL-7Ra) are associated with multiple sclerosis risk and disability progression in Central European Slovak population

J Neuroimmunol. 2015 May 15:282:80-4. doi: 10.1016/j.jneuroim.2015.03.010. Epub 2015 Mar 18.

Abstract

In this study, we determined the association between rs6897932 in interleukin 7 receptor α (IL7Ra) gene and the risk and disability progression of multiple sclerosis (MS) in 270 MS patients and 303 controls. We found allele C to be associated with the risk of MS and minor allele T to be protective against MS development. Moreover, we revealed for the first time that rs6897932 in IL7Ra gene is associated with the progression of MS, evaluated by MSSS scores. The minor allele T and genotype TT are protective against a rapid disability progression in MS in the Central European Slovak population.

Keywords: Disability progression; Gene polymorphism; IL7 receptor alpha gene; MSSS; Multiple sclerosis; rs6897932.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Disabled Persons*
  • Disease Progression
  • Female
  • Gene Frequency
  • Genetic Association Studies
  • Genetic Predisposition to Disease / genetics*
  • Genotype
  • Humans
  • Interleukin-7 Receptor alpha Subunit / genetics*
  • Male
  • Middle Aged
  • Multiple Sclerosis / genetics*
  • Multiple Sclerosis / physiopathology*
  • Polymorphism, Single Nucleotide / genetics*
  • Slovakia

Substances

  • Interleukin-7 Receptor alpha Subunit