Global spectrum of copy number variations reveals genome organizational plasticity and proposes new migration routes

Avinash M Veerappa; Sangeetha Vishweswaraiah; Kusuma Lingaiah; Megha Murthy; Raviraj V Suresh; Dinesh S Manjegowda; Nallur B Ramachandra

doi:10.1371/journal.pone.0121846

Global spectrum of copy number variations reveals genome organizational plasticity and proposes new migration routes

PLoS One. 2015 Apr 24;10(4):e0121846. doi: 10.1371/journal.pone.0121846. eCollection 2015.

Authors

Avinash M Veerappa¹, Sangeetha Vishweswaraiah¹, Kusuma Lingaiah¹, Megha Murthy¹, Raviraj V Suresh¹, Dinesh S Manjegowda², Nallur B Ramachandra¹

Affiliations

¹ Genetics and Genomics Lab, Department of Studies in Zoology, University of Mysore, Manasagangotri, Mysore-06, Karnataka, India.
² NUCSER, KS Hegde Medical Academy, Nitte University, Mangalore-18, Karnataka, India.

Abstract

Global spectrum of CNVs is required to catalog variations to provide a high-resolution on the dynamics of genome-organization and human migration. In this study, we performed genome-wide genotyping using high-resolution arrays and identified 44,109 CNVs from 1,715 genomes across 12 populations. The study unraveled the force of independent evolutionary dynamics on genome-organizational plasticity across populations. We demonstrated the use of CNV tool to study human migration and identified a second major settlement establishing new migration routes in addition to existing ones.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Chromosome Breakpoints
Chromosome Deletion
Chromosome Duplication
Computational Biology / methods
DNA Copy Number Variations*
Evolution, Molecular
Gene Frequency
Genetics, Population*
Genome, Human*
Genome-Wide Association Study
Genomics*
Human Migration*
Humans
Phylogeny
Polymorphism, Single Nucleotide
Reproducibility of Results

Associated data

figshare/10.6084/M9.FIGSHARE.1320382

Grants and funding

The work was supported by Department of Science and Technology-Health Science, grant number SR/SO/HS-103/2007, funding website - http://www.dst.gov.in/. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.