B-cell receptor usage correlates with the sensitivity to CD40 stimulation and the occurrence of CD4+ T-cell clonality in chronic lymphocytic leukemia

Haematologica. 2015 Aug;100(8):e307-10. doi: 10.3324/haematol.2015.124719. Epub 2015 Apr 24.
No abstract available

Keywords: B-cell receptor usage; CD4 positive; CD40 stimulation; T-cell clonality; chronic lymphocytic leukemia.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • CD4-Positive T-Lymphocytes / immunology*
  • CD4-Positive T-Lymphocytes / metabolism*
  • CD40 Antigens / immunology*
  • Clonal Evolution* / genetics
  • Clonal Evolution* / immunology
  • Complementarity Determining Regions / genetics
  • Humans
  • Immunoglobulin Heavy Chains / genetics
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics
  • Leukemia, Lymphocytic, Chronic, B-Cell / immunology*
  • Leukemia, Lymphocytic, Chronic, B-Cell / metabolism*
  • Mutation
  • Receptors, Antigen, B-Cell / genetics
  • Receptors, Antigen, B-Cell / metabolism*

Substances

  • CD40 Antigens
  • Complementarity Determining Regions
  • Immunoglobulin Heavy Chains
  • Receptors, Antigen, B-Cell