Multiple hormonal resistances: Diagnosis, evaluation and therapy

Ann Endocrinol (Paris). 2015 May;76(2):98-100. doi: 10.1016/j.ando.2015.03.029. Epub 2015 Apr 23.

Abstract

Molecular alterations of cAMP-mediated signaling affect primarily the signaling of the PTH/PTHrp receptor, and, with different severities the signaling of other hormones, including TSH. The identification of PTH and other hormonal resistances implies to look for the genetic disorder supporting the metabolic disorder.

Keywords: Acrodysostose; Acrodysostosis; G-protein coupled receptor; PTH resistance; Pseudohypoparathyroidie; Pseudohypoparathyroidism; Récepteur couplé aux protéines G; Résistance à la PTH.

Publication types

  • Review

MeSH terms

  • Humans
  • Parathyroid Diseases / diagnosis
  • Parathyroid Diseases / physiopathology
  • Parathyroid Diseases / therapy*
  • Parathyroid Hormone / physiology*
  • Pseudohypoparathyroidism / genetics
  • Pseudohypoparathyroidism / therapy
  • Receptors, Parathyroid Hormone / genetics
  • Receptors, Parathyroid Hormone / metabolism
  • Thyrotropin / physiology

Substances

  • Parathyroid Hormone
  • Receptors, Parathyroid Hormone
  • Thyrotropin