1 From the IMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, Victoria, Australia; the Orygen Youth Health Research Centre, Centre for Youth Mental Health, University of Melbourne, Parkville, Victoria, Australia; Barwon Health and the Geelong Clinic, Geelong; the Florey Institute for Neuroscience and Mental Health, Parkville; the Department of Psychiatry, University of Melbourne, Parkville; and the Bipolar Clinic and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston.