Sternberg working memory performance following treatment with pramipexole in patients with moderate-to-severe restless legs syndrome

Ki-Young Jung; Sung Min Kim; Jin-Young Song; Byeong Uk Lee; Chany Lee; Sang Kun Lee; Yong Seo Koo; Yong Won Cho; Jeong Woo Choi; Kyung Hwan Kim

doi:10.1016/j.sleep.2014.10.025

Sternberg working memory performance following treatment with pramipexole in patients with moderate-to-severe restless legs syndrome

Sleep Med. 2015 Jun;16(6):703-8. doi: 10.1016/j.sleep.2014.10.025. Epub 2015 Feb 27.

Authors

Affiliations

¹ Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea. Electronic address: [email protected].
² Department of Neurology, Korea University Medical Center Anam Hospital, Korea University College of Medicine, Seoul, South Korea.
³ Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
⁴ Department of Biomedical Engineering, Hanyang University, Seoul, South Korea.
⁵ Department of Neurology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, South Korea.
⁶ Department of Biomedical Engineering, College of Health Science, Yonsei University, Wonju, Gangwon-do, South Korea.
⁷ Department of Biomedical Engineering, College of Health Science, Yonsei University, Wonju, Gangwon-do, South Korea. Electronic address: [email protected].

PMID: 25934537
DOI: 10.1016/j.sleep.2014.10.025

Abstract

Objectives: We recently reported that the P300 amplitude related to the Sternberg working memory (WM) task was significantly lower in drug-naïve severe restless legs syndrome (RLS) patients than controls. Here, we evaluated the effects of pramipexole on the Sternberg WM task performance by event-related potential (ERP) study.

Methods: Thirteen drug-naïve RLS patients (52.0 ± 9.48 years) were enrolled in the study. Pramipexole was administered over a period of 12 weeks every night 1 h before bedtime. Two ERP studies were carried out: the first was performed just before giving the first dose of pramipexole and the second was conducted at 12-16 weeks after commencement of pramipexole administration. P300 amplitudes and reaction times were compared before and after treatment considering brain regions and memory load as within-subject factors. Clinical and sleep-related variables were correlated with P300 amplitude.

Results: After treatment with pramipexole, the International RLS Severity Scale (IRLS) score was significantly decreased. Sleep quality and depression were also significantly improved. Omission error was significantly reduced without significant change of commission error. Reaction time was significantly shortened, regardless of memory load size, following treatment with pramipexole. Parietal P300 amplitude was significantly increased after treatment with pramipexole for all memory load sizes. Increase of frontal P300 amplitude was significantly correlated with improvement of sleep duration, IRLS, Insomnia Severity Index, and Pittsburgh Sleep Quality Index score.

Conclusion: Our study suggested that pramipexole improves WM performance in patients with RLS in addition to improving RLS symptoms, sleep disturbance, and depression.

Keywords: Dopamine agonist; Event-related potential; P300; Pramipexole; Restless legs syndrome; Working memory.

Publication types

Clinical Study
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Benzothiazoles / adverse effects*
Benzothiazoles / therapeutic use*
Depression / drug therapy
Depression / psychology
Dose-Response Relationship, Drug
Drug Administration Schedule
Event-Related Potentials, P300 / drug effects*
Female
Follow-Up Studies
Humans
Male
Memory, Short-Term / drug effects*
Middle Aged
Neuropsychological Tests
Pramipexole
Reaction Time / drug effects
Restless Legs Syndrome / drug therapy*
Restless Legs Syndrome / psychology

Substances

Benzothiazoles
Pramipexole