No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer

Affiliations

• ¹ Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
• ² Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
• ³ Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA. Electronic address: [email protected].
• ⁴ Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
• ⁵ Comprehensive Cancer Center The Netherlands, Utrecht, The Netherlands; Department for Health Evidence, Radboud University Medical Centre, Nijmegen, The Netherlands.
• ⁶ Landspitali University Hospital, Reykjavik, Iceland; University of Iceland, School of Medicine, Reykjavik, Iceland.
• ⁷ Department of Clinical Genetics, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.
• ⁸ Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.
• ⁹ Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Ontario Cancer Genetics Network, Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
• ¹⁰ Department of Epidemiology, University of California Irvine, Irvine, CA, USA.
• ¹¹ N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus.
• ¹² Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
• ¹³ Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.
• ¹⁴ Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.
• ¹⁵ Department of Gynecology and Obstetrics, University Hospital of Schleswig-Holstein, University Kiel, Kiel, Germany.
• ¹⁶ Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA; Clinical Cancer Genetics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
• ¹⁷ Department of Oncology, Karolinska University Hospital, Stockholm, Sweden.
• ¹⁸ Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London, UK.
• ¹⁹ Cancer Division, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia; Peter MacCallum Cancer Institute, Melbourne, VIC, Australia; Center for Cancer Research, University of Sydney at Westmead Millennium Institute, Sydney, Australia.
• ²⁰ Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
• ²¹ Western Sydney and Nepean Blue Mountains Local Health Districts, Westmead Millennium Institute for Medical Research, University of Sydney, Sydney, Australia.
• ²² Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
• ²³ Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, USA; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.
• ²⁴ Institute for Quality and Efficiency in Health Care (IQWiG), Cologne, Germany.
• ²⁵ University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany.
• ²⁶ Centro Nacional de Genotipación, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain; University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany; Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain.
• ²⁷ Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
• ²⁸ Sheba Medical Center, Tel Aviv, Israel.
• ²⁹ Multidisciplinary Breast Center, University Hospital Leuven, University of Leuven, Belgium.
• ³⁰ Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
• ³¹ Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Bergen, Norway.
• ³² Department of Oncology, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland.
• ³³ Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany; Department of Radiation Oncology, Hannover Medical School, Hannover, Germany.
• ³⁴ Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark.
• ³⁵ Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.
• ³⁶ Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy.
• ³⁷ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
• ³⁸ Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany; University of Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany; Cancer Research Center (DKFZ), Heidelberg, Germany.
• ³⁹ Department of Epidemiology, Cancer Prevention Institute of California, Fremont, CA, USA.
• ⁴⁰ Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
• ⁴¹ Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.
• ⁴² Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI-Catalan Institute of Oncology, Girona, Spain.
• ⁴³ Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bochum, Germany.
• ⁴⁴ Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
• ⁴⁵ Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.
• ⁴⁶ Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany; Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
• ⁴⁷ Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland; Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.
• ⁴⁸ Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.
• ⁴⁹ Section of Genetic Oncology, Department of Laboratory Medicine, University Hospital of Pisa, University of Pisa, Pisa, Italy.
• ⁵⁰ Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Australia; Department of Pathology, University of Melbourne, Melbourne, VIC, Australia.
• ⁵¹ Gynaecological Oncology, The Chris O'Brien Lifehouse and The University of Sydney, Sydney, Australia.
• ⁵² Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
• ⁵³ Center for Medical Genetics, Ghent University, Ghent, Belgium.
• ⁵⁴ Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.
• ⁵⁵ Division of Epidemiology and Biostatistics, University of New Mexico, Albuquerque, NM, USA.
• ⁵⁶ Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA; Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, Rochester, MN, USA.
• ⁵⁷ Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield, UK.
• ⁵⁸ Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
• ⁵⁹ Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK.
• ⁶⁰ Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, Rochester, MN, USA.
• ⁶¹ International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical Academy, Szczecin, Poland.
• ⁶² INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
• ⁶³ Molecular Oncology Laboratory, Hospital Clinico San Carlos, Madrid, Spain.
• ⁶⁴ Center for Cancer Research, University of Sydney at Westmead Millennium Institute, Sydney, Australia; Department of Gynaecological Oncology, Westmead Hospital, Sydney, Australia.
• ⁶⁵ Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
• ⁶⁶ Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
• ⁶⁷ Oncogenetics Laboratory, University Hospital Vall d'Hebron, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
• ⁶⁸ Section of Biostatistics and Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
• ⁶⁹ Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Basser Research Centre, Abramson Cancer Center, The University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
• ⁷⁰ Department of Genetics, University of Pretoria, Pretoria, South Africa.
• ⁷¹ Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany.
• ⁷² Non-Communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK.
• ⁷³ Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Klinik Wiesbaden, Wiesbaden, Germany; Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany.
• ⁷⁴ Centre Hospitalier Universitaire de Québec Research Center, Laval University, Quebec, Canada.
• ⁷⁵ Institute of Biology and Molecular Genetics, Universidad de Valladolid (IBGM-UVA), Valladolid, Spain.
• ⁷⁶ Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
• ⁷⁷ Faculty of Medicine, University of Southampton, University Hospital Southampton, Southampton, UK.
• ⁷⁸ Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Gynecologic Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
• ⁷⁹ Department of Clinical Genetics, Lund University, Lund, Sweden.
• ⁸⁰ Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
• ⁸¹ Institute of Human Genetics, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany.
• ⁸² Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
• ⁸³ University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany; David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, University of California at Los Angeles, CA, USA.
• ⁸⁴ Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain.
• ⁸⁵ Department of Cancer Epidemiology/Clinical Cancer Registry, Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany.
• ⁸⁶ Clinical Cancer Genetics, City of Hope, Duarte, CA, USA; New Mexico Cancer Center, Albuquerque, NM, USA.
• ⁸⁷ Fondazione Istituto FIRC di Oncologia Molecolare (IFOM), Milan, Italy; Cogentech Cancer Genetic Test Laboratory, Milan, Italy.
• ⁸⁸ Molecular Diagnostics Laboratory, Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Centre for Scientific Research Demokritos, Aghia Paraskevi Attikis, Athens, Greece.
• ⁸⁹ Kansas IDeA Network of Biomedical Research Excellence Bioinformatics Core, The University of Kansas Cancer Center, Kansas City, KS, USA.
• ⁹⁰ University of Pennsylvania, Philadelphia, PA, USA.
• ⁹¹ The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel; Institute of Oncology, Sheba Medical Center, Tel-Hashomer, Israel.
• ⁹² Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA.
• ⁹³ Center for Cancer Genetics and Prevention, Dana-Farber Cancer Institute, Boston, MA, USA.
• ⁹⁴ Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
• ⁹⁵ GEMO Study: National Cancer Genetics Network, UNICANCER Genetic Group, France.
• ⁹⁶ Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany; University of Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bochum, Germany; Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany; Institute of Pathology, Medical Faculty of the University of Bonn, Bonn, Germany; Institute of Occupational Medicine and Maritime Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany; Cancer Research Center (DKFZ), Heidelberg, Germany.
• ⁹⁷ Gynaecological Cancer Research Centre, Department of Women's Cancer, Institute for Women's Health, UCL, London, UK.
• ⁹⁸ Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
• ⁹⁹ Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow, UK.
• ¹⁰⁰ Ontario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
• ¹⁰¹ Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
• ¹⁰² Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA.
• ¹⁰³ Gynecological Oncology Unit, The Royal Marsden Hospital, London, UK.
• ¹⁰⁴ Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
• ¹⁰⁵ Department of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland.
• ¹⁰⁶ Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
• ¹⁰⁷ INSERM U1018, CESP (Center for Research in Epidemiology and Population Health), Environmental Epidemiology of Cancer, Villejuif, France; University Paris-Sud, UMRS 1018, Villejuif, France.
• ¹⁰⁸ Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.
• ¹⁰⁹ Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
• ¹¹⁰ Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
• ¹¹¹ Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
• ¹¹² Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland; School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland.
• ¹¹³ The Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON), Coordinating Center: Netherlands Cancer Institute, Amsterdam, The Netherlands.
• ¹¹⁴ University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center, Erlangen, Germany.
• ¹¹⁵ Clinical Cancer Genetics, City of Hope, Duarte, CA, USA.
• ¹¹⁶ Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
• ¹¹⁷ Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
• ¹¹⁸ Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark; Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
• ¹¹⁹ Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
• ¹²⁰ N.N. Petrov Institute of Oncology, St. Petersburg, Russia.
• ¹²¹ Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
• ¹²² Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, State Research Centre Institute for Innovative Medicine, Vilnius, Lithuania.
• ¹²³ Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland; Postgraduate School of Molecular Medicine, Warsaw Medical University, Warsaw, Poland.
• ¹²⁴ Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
• ¹²⁵ Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark.
• ¹²⁶ Department of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland.
• ¹²⁷ Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
• ¹²⁸ School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland; Jyväskylä Central Hospital, Jyväskylä, Finland.
• ¹²⁹ Clinical Genetics Research Laboratory, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
• ¹³⁰ kConFab: Kathleen Cuningham Consortium for Research into Familial Breast Cancer - Peter MacCallum Cancer Center, Melbourne, Australia.
• ¹³¹ Department of Population Health Research, Alberta Health Services-Cancer Care, Calgary, Alberta, Canada; Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada; Department of Oncology, University of Calgary, Calgary, Alberta, Canada.
• ¹³² School of Medicine, National University of Ireland, Galway, Ireland.
• ¹³³ Department for Health Evidence, Radboud University Medical Centre, Nijmegen, The Netherlands; Department of Urology, Radboud University Medical Centre, Nijmegen, The Netherlands.
• ¹³⁴ Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
• ¹³⁵ Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada; Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
• ¹³⁶ Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway; Faculty of Medicine (Faculty Division Ahus), Universitetet i Oslo, Norway.
• ¹³⁷ Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Belgium; Vesalius Research Center (VRC), VIB, Leuven, Belgium.
• ¹³⁸ Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium; Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
• ¹³⁹ Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
• ¹⁴⁰ Genetic and Molecular Epidemiology Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
• ¹⁴¹ Université Paris Sorbonne Cité, UMR-S775 Inserm, Paris, France.
• ¹⁴² Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada.
• ¹⁴³ Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
• ¹⁴⁴ Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.
• ¹⁴⁵ College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USA.
• ¹⁴⁶ Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
• ¹⁴⁷ Center for Individualized Medicine, Mayo Clinic, Scottsdale, AZ, USA.
• ¹⁴⁸ Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Warsaw, Poland.
• ¹⁴⁹ Department of Gynecologic Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
• ¹⁵⁰ Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
• ¹⁵¹ Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany; National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany.
• ¹⁵² Department of Gynecology, Radboud University Medical Centre, Nijmegen, The Netherlands.
• ¹⁵³ Laboratoire de Diagnostic Génétique et Service d'Onco-hématologie, Hopitaux Universitaire de Strasbourg, CHRU Nouvel Hôpital Civil, Strasbourg, France.
• ¹⁵⁴ Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA.
• ¹⁵⁵ Anatomical Pathology, The Alfred Hospital, Melbourne, Australia.
• ¹⁵⁶ Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, Glasgow, UK.
• ¹⁵⁷ Department of Gynecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
• ¹⁵⁸ Servicio de Anatomía Patológica, Hospital Monte Naranco, Oviedo, Spain.
• ¹⁵⁹ Department of Surgical Gynecology and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, Szczecin, Poland.
• ¹⁶⁰ Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
• ¹⁶¹ Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia.
• ¹⁶² Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA; Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Gynecologic Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Women's Cancer Research Program, Magee-Women's Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.
• ¹⁶³ Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Laboratory Medicine Program, University Health Network, Toronto, ON, Canada.
• ¹⁶⁴ Women's College Research Institute, University of Toronto, Toronto, ON, Canada.
• ¹⁶⁵ The University of Texas School of Public Health, Houston, TX, USA.
• ¹⁶⁶ Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.
• ¹⁶⁷ Department of Medicine and Institute for Human Genetics, University of California, San Francisco, CA, USA.
• ¹⁶⁸ Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
• ¹⁶⁹ Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.
• ¹⁷⁰ Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, IL, USA.
• ¹⁷¹ Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
• ¹⁷² University of Groningen, University Medical Center, Department of Genetics, Groningen, The Netherlands.
• ¹⁷³ Human Genetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain; Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain; Genetic and Molecular Epidemiology Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
• ¹⁷⁴ Department of Molecular Medicine, Sapienza University, Rome, Italy.
• ¹⁷⁵ Section of Molecular Diagnostics, Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark.
• ¹⁷⁶ Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori (INT), Milan, Italy.
• ¹⁷⁷ Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
• ¹⁷⁸ Fondazione Istituto FIRC di Oncologia Molecolare (IFOM), Milan, Italy.
• ¹⁷⁹ Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Australia; Division of Cancer Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia; Department of Medicine, St Vincent's Hospital, The University of Melbourne, Victoria, Australia.
• ¹⁸⁰ NRG Oncology Statistics and Data Management Center, Buffalo, NY, USA.
• ¹⁸¹ Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
• ¹⁸² Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
• ¹⁸³ Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Genetics, University of Oulu, Oulu University Hospital, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland.
• ¹⁸⁴ Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale Tumori (INT), Milan, Italy.
• ¹⁸⁵ Basser Research Centre, Abramson Cancer Center, The University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA; Center for Clinical Epidemiology and Biostatistics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
• ¹⁸⁶ Clalit National Israeli Cancer Control Center, Haifa, Israel; Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Technion, Haifa, Israel.
• ¹⁸⁷ Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.
• ¹⁸⁸ NorthShore University Health System, University of Chicago, Evanston, IL, USA.
• ¹⁸⁹ Department of Epidemiology, University of Washington, Seattle, WA, USA; Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
• ¹⁹⁰ Department of Gynecology, Jena University Hospital, Jena, Germany.
• ¹⁹¹ Ohio State University, Columbus, OH, USA.
• ¹⁹² Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy's & St. Thomas' NHS Foundation Trust in partnership with King's College London, London, UK.
• ¹⁹³ Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA; Cancer Prevention, Detection and Control Research Program, Duke Cancer Institute, Durham, NC, USA.
• ¹⁹⁴ Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany; Centre for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Cologne, Germany.
• ¹⁹⁵ Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, UK.
• ¹⁹⁶ Institut für Humangenetik Wiesbaden, Wiesbaden, Germany.
• ¹⁹⁷ Department of Gynecological Oncology, Glasgow Royal Infirmary, Glasgow, UK.
• ¹⁹⁸ INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France; Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon, Centre Léon Bérard, Lyon, France.
• ¹⁹⁹ Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.
• ²⁰⁰ Department of Clinical Genetics, University and Regional Laboratories, Lund University Hospital, Lund, Sweden.
• ²⁰¹ Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, Australia.
• ²⁰² Saarland Cancer Registry, Saarbrücken, Germany.
• ²⁰³ Institut Curie, Department of Tumour Biology, Paris, France; Institut Curie, INSERM U830, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, France.
• ²⁰⁴ Department of Oncology, Lund University, Lund, Sweden.
• ²⁰⁵ Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, UK; Division of Breast Cancer Research, The Institute of Cancer Research, Sutton, Surrey, UK.
• ²⁰⁶ Department of Genetics, Portuguese Oncology Institute, Porto, Portugal; Biomedical Sciences Institute (ICBAS), Porto University, Porto, Portugal.
• ²⁰⁷ Department of Epidemiology, Columbia University, New York, NY, USA.
• ²⁰⁸ Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.
• ²⁰⁹ Latvian Biomedical Research and Study Centre, Riga, Latvia.
• ²¹⁰ Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Quebec, Canada.
• ²¹¹ Divison of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
• ²¹² Department of Surgical Oncology, Leiden University Medical Center, Leiden, The Netherlands.
• ²¹³ Welcome Trust Centre for Human Genetics, University of Oxford, UK; Oxford Biomedical Research Centre, University of Oxford, UK.
• ²¹⁴ Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany; Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota, Colombia.
• ²¹⁵ Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
• ²¹⁶ Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.
• ²¹⁷ Department of Gynecology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
• ²¹⁸ Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
• ²¹⁹ Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany.
• ²²⁰ Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain.
• ²²¹ Department of Epidemiology, Center for Cancer Genetics Research and Prevention, School of Medicine, University of California Irvine, Irvine, CA, USA.
• ²²² Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.