Vitamin D controls apoptosis and proliferation of cutaneous T-cell lymphoma cells

Exp Dermatol. 2015 Oct;24(10):798-800. doi: 10.1111/exd.12746. Epub 2015 May 22.

Authors

Christian Mrotzek¹, Moritz Felcht², Andrea Sommer¹, Alexandra Schrader³, Claus-Detlev Klemke², Marco Herling³, Max Schlaak¹, Mario Fabri^{1

4}

Affiliations

¹ Department of Dermatology, University of Cologne, Cologne, Germany.
² Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karls-University Heidelberg, University Medicine Mannheim, Mannheim, Germany.
³ Laboratory of Lymphocyte Signaling and Oncoproteome, Center for Integrated Oncology (CIO) Köln-Bonn and Cologne Cluster of Excellence in Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
⁴ Center for Molecular Medicine, University of Cologne, Cologne, Germany.

PMID: 25940772
DOI: 10.1111/exd.12746

No abstract available

Keywords: cutaneous T cell lymphoma; vitamin D; vitamin D receptor.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / pharmacology
Apoptosis / drug effects*
Bexarotene
CD4-Positive T-Lymphocytes / metabolism
Cell Line, Tumor
Cell Proliferation / drug effects*
Drug Synergism
Humans
Mycosis Fungoides / blood*
Mycosis Fungoides / etiology
Receptors, Calcitriol / metabolism*
Retinoid X Receptors / metabolism
Sezary Syndrome / blood*
Sezary Syndrome / etiology
Skin Neoplasms / blood*
Skin Neoplasms / etiology
Tetrahydronaphthalenes / pharmacology
Vitamin D / analogs & derivatives*
Vitamin D / blood
Vitamin D / pharmacology
Vitamin D Deficiency / complications

Substances

Antineoplastic Agents
Receptors, Calcitriol
Retinoid X Receptors
Tetrahydronaphthalenes
Vitamin D
1,25-dihydroxyvitamin D
25-hydroxyvitamin D
Bexarotene