Is there a role for monocyte chemoattractant protein-1 in delirium? Novel observations in elderly hip fracture patients

BMC Res Notes. 2015 May 6:8:186. doi: 10.1186/s13104-015-1129-5.

Abstract

Background: Delirium is common, associated with poor outcome, but its pathophysiology remains obscure. The aim of the present study was to study a possible role of monocyte chemoattractant protein-1 (MCP-1) in the development of delirium.

Findings: A prospective cohort of 19 hip fracture patients (median age 83 years) were screened for delirium daily by validated methods. MCP-1 was measured on arrival and postoperatively. The number of patients with a raise in MCP-1 was statistically significantly higher in the group with delirium in the postoperative phase compared to the no-delirium group (5/6 vs. 1/7, p = .03).

Conclusions: MCP-1 might play a role in the development of delirium.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Chemokine CCL2 / blood*
  • Delirium / blood*
  • Female
  • Hip Fractures / blood*
  • Hip Fractures / surgery
  • Humans
  • Male
  • Postoperative Complications / etiology
  • Postoperative Period
  • Preoperative Care

Substances

  • CCL2 protein, human
  • Chemokine CCL2