Docosahexaenoic Acid alleviates atopic dermatitis in mice by generating T regulatory cells and m2 macrophages

Karyn A Haitz; Niroshana Anandasabapathy

doi:10.1038/jid.2014.536

Docosahexaenoic Acid alleviates atopic dermatitis in mice by generating T regulatory cells and m2 macrophages

J Invest Dermatol. 2015 Jun;135(6):1472-1474. doi: 10.1038/jid.2014.536.

Authors

Karyn A Haitz¹, Niroshana Anandasabapathy²

Affiliations

¹ Brigham and Women's Hospital, Harvard Skin Disease Research Center/Department of Dermatology, Boston, Massachusetts, USA.
² Brigham and Women's Hospital, Harvard Skin Disease Research Center/Department of Dermatology, Boston, Massachusetts, USA. Electronic address: [email protected].

PMID: 25964266
DOI: 10.1038/jid.2014.536

Abstract

Han et al. (this issue) describe a novel mechanism by which docosahexaenoic acid (DHA) may suppress atopic dermatitis symptoms in mice. They find that DHA induces FoxP3 T regulatory cells in vivo, M2 macrophages drive transforming growth factor-β and IL-10 conversion of CD4 T cells to CD4 FoxP3 T regulatory cells in vitro, and DHA-treated M2 macrophages suppress atopic dermatitis in mice.

Publication types

Comment

MeSH terms

Animals
Dermatitis, Atopic / drug therapy*
Dermatitis, Atopic / immunology*
Docosahexaenoic Acids / chemistry*
Interleukin-10 / immunology*
Macrophages / immunology*
T-Lymphocytes, Regulatory / immunology*
Transforming Growth Factor beta1 / immunology*

Substances

Transforming Growth Factor beta1
Interleukin-10
Docosahexaenoic Acids