Abstract
Nitraria retusa is a halophyte species that is distributed in North Africa and used as a traditional medicinal plant. In this study, N. retusa ethanol extract and its constituent isorhamnetin (IRA) protected against amyloid β (Aβ)-induced cytotoxicity in human neuroblastoma SH-SY5Y cells. An in vitro Aβ aggregation assay suggested that IRA destabilizes Aβ fibrils.
Keywords:
Alzheimer’s disease; amyloid β; isorhamnetin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alzheimer Disease / drug therapy*
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Alzheimer Disease / pathology
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Amyloid / drug effects
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Amyloid beta-Peptides / metabolism
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Cell Line
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Cell Proliferation / drug effects
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Humans
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Magnoliopsida / chemistry
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Plant Extracts / administration & dosage*
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Plant Extracts / chemistry
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Protein Aggregation, Pathological / drug therapy*
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Protein Aggregation, Pathological / pathology
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Quercetin / administration & dosage
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Quercetin / analogs & derivatives*
Substances
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Amyloid
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Amyloid beta-Peptides
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Plant Extracts
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3-methylquercetin
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Quercetin