Abstract
Various studies have assessed the clinicopathological and prognostic value of Notch1 and Notch3 expression in Non-small cell lung cancer (NSCLC), but their results remain controversial. This meta-analysis was conducted to address the above issues by using a total of 19 studies involving 3663 patients. The correlations between Notch1 and Notch3 expression and clinicopathological features and NSCLC prognosis were analyzed. The meta-analysis indicated that higher expression of Notch1 was associated with greater possibility of lymph node metastasis and higher TNM stages. Moreover, patients with Notch1 overexpression and Notch3 overexpression showed significantly poor overall survival (Notch1: HR, 1.29; 95% CI, 1.06-1.57, p = 0.468 and I(2) = 0.0%; Notch3: HR, 1.57; 95%CI, 1.04-2.36, p = 0.445 and I(2) = 0.0%). Furthermore, there are statistically significant association between overall survival of NSCLC patients and the expression of Notch signaling ligand DLL3 and target gene HES1. Our meta-analysis supports that Notch signaling is a valuable bio-marker to predict progression and targeting Notch signaling could benefit subpopulation of NSCLC patients.
Publication types
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Meta-Analysis
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Research Support, Non-U.S. Gov't
MeSH terms
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Basic Helix-Loop-Helix Transcription Factors / genetics
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Basic Helix-Loop-Helix Transcription Factors / metabolism
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Biomarkers, Tumor / genetics
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Biomarkers, Tumor / metabolism
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Carcinoma, Non-Small-Cell Lung / diagnosis*
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Carcinoma, Non-Small-Cell Lung / metabolism
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Carcinoma, Non-Small-Cell Lung / mortality
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Carcinoma, Non-Small-Cell Lung / pathology*
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Databases, Factual
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Disease Progression
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Homeodomain Proteins / genetics
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Homeodomain Proteins / metabolism
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Humans
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Intracellular Signaling Peptides and Proteins / genetics
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Intracellular Signaling Peptides and Proteins / metabolism
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Lung Neoplasms / metabolism
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Lung Neoplasms / pathology*
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Lymphatic Metastasis
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Membrane Proteins / genetics
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Membrane Proteins / metabolism
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Neoplasm Staging
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Prognosis
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Proportional Hazards Models
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Receptor, Notch1 / genetics
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Receptor, Notch1 / metabolism*
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Receptor, Notch3
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Receptors, Notch / genetics
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Receptors, Notch / metabolism*
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Signal Transduction
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Survival Rate
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Transcription Factor HES-1
Substances
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Basic Helix-Loop-Helix Transcription Factors
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Biomarkers, Tumor
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DLL3 protein, human
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Homeodomain Proteins
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Intracellular Signaling Peptides and Proteins
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Membrane Proteins
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NOTCH1 protein, human
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NOTCH3 protein, human
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Receptor, Notch1
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Receptor, Notch3
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Receptors, Notch
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Transcription Factor HES-1
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HES1 protein, human