Smart Albumin-Biomineralized Nanocomposites for Multimodal Imaging and Photothermal Tumor Ablation

Yong Wang; Tao Yang; Hengte Ke; Aijun Zhu; Yangyun Wang; Junxin Wang; Junkang Shen; Gang Liu; Chunying Chen; Yuliang Zhao; Huabing Chen

doi:10.1002/adma.201500229

Smart Albumin-Biomineralized Nanocomposites for Multimodal Imaging and Photothermal Tumor Ablation

Adv Mater. 2015 Jul 8;27(26):3874-82. doi: 10.1002/adma.201500229. Epub 2015 May 21.

Authors

Yong Wang¹, Tao Yang², Hengte Ke², Aijun Zhu², Yangyun Wang¹, Junxin Wang³, Junkang Shen³, Gang Liu⁴, Chunying Chen⁵, Yuliang Zhao⁵, Huabing Chen^{1

2}

Affiliations

¹ School of Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, School of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, China.
² Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, Jiangsu, China.
³ Radiology Department, Second Affiliated Hospital, Soochow University, Suzhou, 215004, China.
⁴ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China.
⁵ CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing, 100190, China.

PMID: 25997571
DOI: 10.1002/adma.201500229

Abstract

Smart cyanine-grafted gadolinium oxide nanocrystals (Cy-GdNCs) obtained by albumin-based biomineralization are shown to be theranostic nanocomposites, with promising properties for trimodal near-infrared fluorescence/photoacoustics/magnetic-resonance imaging-guided photothermal tumor ablation.

Keywords: biomineralization; multimodal imaging; nanocomposites; photothermal therapies; tumor ablations.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Ablation Techniques / methods*
Animals
Cattle
Cell Line, Tumor
Gadolinium / chemistry
Hydrogen-Ion Concentration
Indoles / chemistry
Mammary Neoplasms, Experimental / diagnosis*
Mammary Neoplasms, Experimental / pathology
Mammary Neoplasms, Experimental / therapy*
Mice
Minerals / chemistry
Minerals / metabolism*
Models, Molecular
Multimodal Imaging / methods*
Nanocomposites / chemistry*
Nanocomposites / therapeutic use
Nanoparticles / chemistry
Phototherapy
Propionates / chemistry
Protein Conformation
Serum Albumin, Bovine / chemistry
Serum Albumin, Bovine / metabolism*
Theranostic Nanomedicine

Substances

Cypate
Indoles
Minerals
Propionates
Serum Albumin, Bovine
gadolinium oxide
Gadolinium