Abstract
Herein, we report a biocompatible amphiphilic block copolymer micelle bearing a singlet oxygen-sensitive vinyldithioether cleavable linker at the core-shell junction, which undergoes singlet oxygen-mediated photocleavage in the presence of visible light. The micelle facilitates the light-responsive release of singlet oxygen and an anticancer drug for enhanced photodynamic therapy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Biocompatible Materials / chemistry
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Cell Line, Tumor
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Doxorubicin / chemistry*
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Doxorubicin / pharmacology
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Drug Carriers / chemistry
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Drug Design
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Drug Liberation
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Humans
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Hydrophobic and Hydrophilic Interactions
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Intracellular Space / drug effects
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Intracellular Space / metabolism*
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Intracellular Space / radiation effects
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Lactones / chemistry*
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Light*
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Micelles*
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Photochemotherapy*
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Photosensitizing Agents / chemistry
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Photosensitizing Agents / pharmacology
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Polyethylene Glycols / chemistry*
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Singlet Oxygen / metabolism*
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Sulfides / chemistry
Substances
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Antineoplastic Agents
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Biocompatible Materials
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Drug Carriers
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Lactones
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Micelles
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Photosensitizing Agents
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Sulfides
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poly(ethylene glycol)-block-poly(epsilon-caprolactone)
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Singlet Oxygen
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Polyethylene Glycols
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Doxorubicin