Cerebrospinal fluid CXCL13 in clinically isolated syndrome patients: Association with oligoclonal IgM bands and prediction of Multiple Sclerosis diagnosis

Diana Ferraro; Veronica Galli; Francesca Vitetta; Anna Maria Simone; Roberta Bedin; Cinzia Del Giovane; Franca Morselli; Maria Maddalena Filippini; Paolo Frigio Nichelli; Patrizia Sola

doi:10.1016/j.jneuroim.2015.04.011

Cerebrospinal fluid CXCL13 in clinically isolated syndrome patients: Association with oligoclonal IgM bands and prediction of Multiple Sclerosis diagnosis

J Neuroimmunol. 2015 Jun 15:283:64-9. doi: 10.1016/j.jneuroim.2015.04.011. Epub 2015 Apr 25.

Authors

Affiliations

¹ Neurology Unit, Department of Biomedical, Metabolic and Neurosciences, University of Modena and Reggio Emilia, Via Pietro Giardini, 1355, 41126 Modena, Italy. Electronic address: [email protected].
² Neuroimmunology Laboratory, Department of Biomedical, Metabolic and Neurosciences, University of Modena and Reggio Emilia, Via Pietro Giardini, 1355, 41126 Modena, Italy. Electronic address: [email protected].
³ Neurology Unit, Department of Biomedical, Metabolic and Neurosciences, University of Modena and Reggio Emilia, Via Pietro Giardini, 1355, 41126 Modena, Italy. Electronic address: [email protected].
⁴ Neurology Unit, Department of Biomedical, Metabolic and Neurosciences, University of Modena and Reggio Emilia, Via Pietro Giardini, 1355, 41126 Modena, Italy. Electronic address: [email protected].
⁵ Neuroimmunology Laboratory, Department of Biomedical, Metabolic and Neurosciences, University of Modena and Reggio Emilia, Via Pietro Giardini, 1355, 41126 Modena, Italy. Electronic address: [email protected].
⁶ Department of Diagnostic and Clinical Medicine and Public Health, University of Modena and Reggio Emilia, Via del Pozzo, 70, 41100 Modena, Italy. Electronic address: [email protected].
⁷ Neurology Unit, Department of Biomedical, Metabolic and Neurosciences, University of Modena and Reggio Emilia, Via Pietro Giardini, 1355, 41126 Modena, Italy. Electronic address: [email protected].
⁸ Neurology Unit, Department of Biomedical, Metabolic and Neurosciences, University of Modena and Reggio Emilia, Via Pietro Giardini, 1355, 41126 Modena, Italy. Electronic address: [email protected].
⁹ Neurology Unit, Department of Biomedical, Metabolic and Neurosciences, University of Modena and Reggio Emilia, Via Pietro Giardini, 1355, 41126 Modena, Italy. Electronic address: [email protected].
¹⁰ Neurology Unit, Department of Biomedical, Metabolic and Neurosciences, University of Modena and Reggio Emilia, Via Pietro Giardini, 1355, 41126 Modena, Italy. Electronic address: [email protected].

PMID: 26004159
DOI: 10.1016/j.jneuroim.2015.04.011

Abstract

Cerebrospinal fluid (CSF) CXCL13 was shown to correlate with markers of intrathecal inflammation and CSF oligoclonal IgM bands (IgMOB) have been associated with a more severe Multiple Sclerosis (MS) course. We correlated CSF CXCL13 levels with clinical, MRI and CSF parameters, including CSF IgMOB, in 110 Clinically Isolated Syndrome (CIS) patients. CSF CXCL13 levels correlated with CSF cell count, total protein, IgG Index and with the presence of CSF IgGOB and IgMOB. CSF CXCL13 levels ≥15.4 pg/ml showed a good positive predictive value and specificity for a MS diagnosis and for a clinical relapse within one year from onset.

Keywords: CXCL13; Cerebrospinal fluid; Clinically Isolated Syndrome; IgM oligoclonal bands; Multiple Sclerosis; Relapsing–remitting.

Publication types

Comparative Study

MeSH terms

Adult
Brain / pathology
Chemokine CXCL13 / blood
Chemokine CXCL13 / cerebrospinal fluid*
Disease-Free Survival
Female
Follow-Up Studies
Humans
Kaplan-Meier Estimate
Magnetic Resonance Imaging
Male
Middle Aged
Multiple Sclerosis / blood
Multiple Sclerosis / cerebrospinal fluid*
Multiple Sclerosis / diagnosis
Multiple Sclerosis / immunology
Oligoclonal Bands / blood
Oligoclonal Bands / cerebrospinal fluid*
Predictive Value of Tests
Recurrence
Risk Factors
Spinal Cord / pathology
Young Adult

Substances

CXCL13 protein, human
Chemokine CXCL13
Oligoclonal Bands