Severe combined immunodeficiency (SCID) presenting with neonatal aplastic anemia

Angela Scott; Jason Glover; Suzanne Skoda-Smith; Troy R Torgerson; Min Xu; Lauri M Burroughs; Ann E Woolfrey; Mark D Fleming; Akiko Shimamura

doi:10.1002/pbc.25587

Severe combined immunodeficiency (SCID) presenting with neonatal aplastic anemia

Pediatr Blood Cancer. 2015 Nov;62(11):2047-9. doi: 10.1002/pbc.25587. Epub 2015 May 22.

Authors

Angela Scott^{1

2

3}, Jason Glover⁴, Suzanne Skoda-Smith^{5

6}, Troy R Torgerson^{5

6}, Min Xu^{7

8}, Lauri M Burroughs^{1

2

3}, Ann E Woolfrey^{1

2

3}, Mark D Fleming⁹, Akiko Shimamura^{1

2

3}

Affiliations

¹ Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
² Department of Pediatric Hematology and Oncology, Seattle Children's Hospital, Seattle, Washington.
³ Department of Pediatrics, University of Washington, Seattle, Washington.
⁴ Department of Pediatric Hematology and Oncology, Children's Cancer and Blood Disorders Program, Randall Children's Hospital at Legacy Emanuel, Portland, Oregon.
⁵ Department of Immunology, Seattle Children's Hospital, Seattle, Washington.
⁶ Department of Pediatrics, Immunology Division, University of Washington, Seattle, Washington.
⁷ Department of Laboratory Medicine and Pathology, Seattle Children's Hospital, Seattle, Washington.
⁸ Department of Laboratory Medicine, University of Washington, Seattle, Washington.
⁹ Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

Abstract

Aplastic anemia in the neonate is rare. We report a case of severe combined immunodeficiency (SCID) presenting with neonatal aplastic anemia. This report highlights the importance of considering SCID early in the evaluation of neonatal aplastic anemia prior to the development of infectious complications.

Keywords: aplastic anemia; neonatal; severe combined immunodeficiency (SCID).

Publication types

Case Reports
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Anemia, Aplastic* / complications
Anemia, Aplastic* / pathology
Anemia, Aplastic* / therapy
Humans
Infant, Newborn
Male
Severe Combined Immunodeficiency* / complications
Severe Combined Immunodeficiency* / pathology
Severe Combined Immunodeficiency* / therapy

Grants and funding

R24 DK099808/DK/NIDDK NIH HHS/United States