Arterial hypotension and prerenal failure in an extremely preterm infant associated with oral sildenafil

H Balasubramanian; T Strunk; R Kohan

doi:10.1038/jp.2015.31

Arterial hypotension and prerenal failure in an extremely preterm infant associated with oral sildenafil

J Perinatol. 2015 Jun;35(6):458-9. doi: 10.1038/jp.2015.31.

Authors

H Balasubramanian¹, T Strunk², R Kohan²

Affiliations

¹ Neonatal Clinical Care Unit, King Edward Memorial Hospital for Women, Perth, WA, Australia.
² 1] Neonatal Clinical Care Unit, King Edward Memorial Hospital for Women, Perth, WA, Australia [2] Centre for Neonatal Research and Education, School of Paediatrics and Child Health University of Western Australia, Perth, WA, Australia.

PMID: 26012476
DOI: 10.1038/jp.2015.31

Abstract

We report significant hypotension and prerenal failure in an extremely preterm infant following two doses of oral sildenafil that warranted discontinuation of the drug and treatment with inotropes. Blood pressure and urine output normalized after 24 h of withdrawal of the oral drug. Sildenafil should be used cautiously in extremely preterm infants early in the neonatal course, where there is limited data on its efficacy and safety.

Publication types

Case Reports

MeSH terms

Acidosis, Lactic / chemically induced
Administration, Oral
Female
Humans
Hypotension / chemically induced*
Hypotension / therapy
Infant, Extremely Premature*
Infant, Newborn
Kidney / blood supply
Persistent Fetal Circulation Syndrome / drug therapy*
Sildenafil Citrate / administration & dosage
Sildenafil Citrate / adverse effects*
Sildenafil Citrate / therapeutic use
Vasodilator Agents / administration & dosage
Vasodilator Agents / adverse effects*
Vasodilator Agents / therapeutic use

Substances

Vasodilator Agents
Sildenafil Citrate