Prospective analysis of cardiac collapsibility of inferior vena cava using ultrasonography

Purpose: The inferior vena cava (IVC) diameter and its respiratory change (respiratory variation) reportedly correlate well with the central venous pressure and response to fluid. However, changes in the IVC diameter are related to the cardiac rhythm (cardiac variation), which can be useful as an indicator for intravascular volume but can affect respiratory variation. We conducted a prospective analysis of this cardiac variation in adult emergency department patients.

Methods: Ultrasonographic IVC images from 190 consecutive adult emergency department patients were collected prospectively. The IVC diameters 2 cm caudal from the middle hepatic vein were tracked automatically and measured. The IVC diameter changes were analyzed using a software program that tracks 2-dimensional motion in B-mode images. Cardiac and respiratory variations were calculated and analyzed.

Results: The average IVC cardiac variation was 11.0% (95% confidence interval, 9.8%-12.3%) in these patients, which affects the respiratory variation resulting in 1.68-fold higher overestimation of respiratory variation. The coefficient of correlation between IVC cardiac variations and respiratory variations was 0.34 (P < .05).

Conclusions: The IVC cardiac variation affects our interpretation of ultrasonography IVC imaging. The IVC cardiac variation provides several advantages over other parameters of intravascular volume. Therefore, it can be a novel tool to assess the intravascular volume of the patients.