MR appearance of parathyroid adenomas at 3 T in patients with primary hyperparathyroidism: what radiologists need to know for pre-operative localization

Eur Radiol. 2016 Mar;26(3):664-73. doi: 10.1007/s00330-015-3854-5. Epub 2015 May 31.

Abstract

Objectives: To identify frequent MRI features of parathyroid adenomas (PTAs) in patients with primary hyperparathyroidism (PHPT) using a fast protocol with a 3 T magnet.

Methods: Thirty-eight patients with PHPT underwent a 3 T-MR. All patients had positive US and Tc-99 sestamibi, for a total number of 46 PTAs. T2-weighted IDEAL-FSE and T1 IDEAL-sequences, before and after contrast, were performed. Five features of PTAs were recognised: hyperintensity, homogeneous or "marbled" appearance and elongated morphology on T2-sequences; cleavage plane from thyroid gland on T2-outphase; rapid enhancement in post-contrast T1. Image quality for T2-weighted IDEAL FSE and usefulness for IDEAL post-contrast T1-weighted and T2-outphase sequences were also graded.

Results: PTAs were hyperintense in T2-sequences in 44/46 (95.7%), "marbled" in 30/46 (65.2%) and elongated in 38/46 (82.6%) patients. Cleavage plane was observed in 36/46 (78.3%), and rapid enhancement in 20/46 (43.5%) patients. T2-sequences showed both excellent fat suppression and image quality (average scores of 3.2 and 3.1). T2-outphase images demonstrated to be quite useful (score 2.8), whereas, post-contrast T1 images showed a lower degree of utility (score 2.4).

Conclusions: A fast protocol with 3.0-T MRI, recognising most common features of PTAs, may be used as a second-line method in the preoperative detection of PTAs.

Key points: 3 T MRI protocol based on T2-weighted IDEAL FSE sequences was used. T2-hyperintensity and elongated morphology are common features of PTAs. 3 T MRI could be used in the preoperative detection of PTAs.

Keywords: 3 T Magnetic Resonance Imaging; IDEAL sequences; Parathyroid adenoma; Presurgical localisation; Primary hyperparathyroidism.

MeSH terms

  • Adenoma / diagnosis*
  • Adenoma / diagnostic imaging
  • Adenoma / pathology
  • Adult
  • Aged
  • Aged, 80 and over
  • Contrast Media
  • Female
  • Follow-Up Studies
  • Humans
  • Hyperparathyroidism, Primary / complications*
  • Image Enhancement / methods
  • Magnetic Resonance Imaging / methods*
  • Magnetic Resonance Imaging / statistics & numerical data
  • Male
  • Middle Aged
  • Minimally Invasive Surgical Procedures
  • Multimodal Imaging / methods
  • Neck / surgery
  • Parathyroid Neoplasms / diagnosis*
  • Parathyroid Neoplasms / diagnostic imaging
  • Parathyroid Neoplasms / pathology
  • Prospective Studies
  • Radiopharmaceuticals
  • Technetium Tc 99m Sestamibi
  • Ultrasonography
  • Young Adult

Substances

  • Contrast Media
  • Radiopharmaceuticals
  • Technetium Tc 99m Sestamibi