Abstract
In this study, we propose a single solution for prevention of postoperative complications and recurrence of highly metastatic gastrointestinal tract cancers. Here, we demonstrate preparation and characterization of Taiwanin A incorporated polyurethane fiber sheets with excellent mechanical properties and sustained drug release. Sheets with elastic modulus of 8 MPa and ultimate tensile strength of 30 MPa will provide support on surgical staple line preventing leakage at anastomosis. Slight burst release of the drug within 7 days (15%) and further sustained release will inhibit proliferation and migration of remaining cancer cells and maintain locoregional high drug concentration to prevent recurrence of the disease. High elasticity of the material will promote healing process without impeding natural peristalsis movement of gastrointestinal organs.
Keywords:
Taiwanin A; cancer recurrence; controlled drug release; nanofiber; polyurethane.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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3T3 Cells
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Anastomotic Leak / prevention & control
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Animals
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Antineoplastic Agents, Phytogenic / administration & dosage
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Antineoplastic Agents, Phytogenic / adverse effects
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / pharmacology
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Biocompatible Materials / adverse effects
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Biocompatible Materials / chemistry*
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Cell Line, Tumor
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Cell Movement / drug effects
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Cell Survival / drug effects
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Combined Modality Therapy
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Delayed-Action Preparations / administration & dosage
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Delayed-Action Preparations / adverse effects
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Delayed-Action Preparations / chemistry
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Delayed-Action Preparations / pharmacology
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Drug Delivery Systems* / adverse effects
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Drug Liberation
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Elastic Modulus
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Furans / administration & dosage
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Furans / adverse effects
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Furans / chemistry*
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Furans / pharmacology
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Gastrointestinal Neoplasms / drug therapy
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Gastrointestinal Neoplasms / pathology
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Gastrointestinal Neoplasms / prevention & control
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Gastrointestinal Neoplasms / surgery
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Humans
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Lignans / administration & dosage
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Lignans / adverse effects
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Lignans / chemistry*
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Lignans / pharmacology
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Membranes, Artificial*
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Mice
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Neoplasm Recurrence, Local / prevention & control
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Polyurethanes / adverse effects
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Polyurethanes / chemistry*
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Postoperative Complications / prevention & control*
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Surface Properties
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Tensile Strength
Substances
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Antineoplastic Agents, Phytogenic
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Biocompatible Materials
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Delayed-Action Preparations
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Furans
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Lignans
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Membranes, Artificial
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Polyurethanes
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taiwanin A