MEIC Evaluation of Acute Systemic Toxicity: Part VI. The Prediction of Human Toxicity by Rodent LD50 Values and Results From 61 In Vitro Methods
Altern Lab Anim
.
1998 Aug:26 Suppl 2:617-58.
Authors
B Ekwall
1
,
F A Barile
2
,
A Castano
3
,
C Clemedson
1
,
R H Clothier
4
,
P Dierickx
5
,
B Ekwall
1
,
M Ferro
6
,
G Fiskesjö
7
,
L Garza-Ocañas
8
,
M J Gómez-Lechón
9
,
M Gülden
10
,
T Hall
11
,
B Isomaa
12
,
A Kahru
13
,
G Kerszman
14
,
U Kristen
15
,
M Kunimoto
16
,
S Kärenlampi
17
,
L Lewan
18
,
A Loukianov
19
,
T Ohno
20
,
G Persoone
21
,
L Romert
22
,
T W Sawyer
23
,
R Shrivastava
24
,
H Segner
25
,
A Stammati
26
,
N Tanaka
27
,
M Valentino
28
,
E Walum
22
,
F Zucco
29
Affiliations
1
CTLU, Stånga, Sweden.
2
Department of Natural Sciences, York College, City University of New York, USA.
3
Environmental Toxicology, Centro de Investigacion en Sanidad Animal, Valdeolmos, Madrid, Spain.
4
School of Biomedical Sciences, Queen's Medical Centre, Nottingham, UK.
5
Instituut voor Hygiene en Epidemiologie, Brussels, Belgium.
6
Institute of General Pathology, Genova, Italy.
7
Department of Genetics, University of Lund, Lund, Sweden.
8
Departament de Farmacologia y Toxicologia, Facultad de Medicina, Universidad Autonoma de Nuevo Leon, Nuevo Leon, Mexico.
9
Cultivos Celulares, Centro Investigacion, Hospital La Fe, Valencia, Spain.
10
Institut für Toxicologie, Zelltoxikologie, Christian-Albrechts-Universität, Kiel, Germany.
11
MD Laboratories, Bartenheim, France.
12
Department of Biology, Åbo Akademi University, Åbo, Finland.
13
Laboratory for Molecular Genetics, Institute of Chemical Physics and Biophysics, Estonian Academy of Sciences, Tallinn, Estonia.
14
Institute of Life Science and Chemistry, Roskilde, Denmark.
15
Institut für Allgemeine Botanik, Universität Hamburg, Hamburg, Germany.
16
Environmental Health Sciences Division, National Institute of Environmental Studies - NIES, Ibaraki, Japan.
17
Department of Biochemistry and Biotechnology, University of Kuopio, Kuopio, Finland.
18
Department of Animal Physiology, University of Lund, Lund, Sweden.
19
CETA - Centre for Ethical Treatment of Animals, Moscow, Russia.
20
RIKEN Cell Bank, Institute of Physical and Chemical Research RIKEN, Tsukuba City, Ibaraki, Japan.
21
Laboratory for Biological Research in Aquatic Pollution, University of Ghent, Ghent, Belgium.
22
Pharmacia and Upjohn, Stockholm, Sweden.
23
Biomedical Defence Section, Defence Research Establishment Suffield-DRES, Alberta, Canada.
24
Vitro-Bio, Le Breuil-Sur-Couze, France.
25
Umweltforschungs-zentrum, Leipzig-Halle GmbH, Leipzig, Germany.
26
Department of Comparative Toxicology and Ecotoxicology, Istituto Superiore di Sanita, Roma, Italy.
27
Hatano Research Institute, Food and Drug Safety Center, Kanagawa, Japan.
28
Universita di Ancona, Clinica del Lavoro, Ospedale Regionale, Ancona, Italy.
29
Istituto Tecnologie Biomediche, Consiglio Nationale delle Recherche, Roma, Italy.
PMID:
26042663
No abstract available