Abstract
In this issue of Blood, Peterson et al demonstrate that inhibition of both Usp9x and Usp24 results in efficient degradation of Mcl-1, induction of apoptosis, and inhibition of tumor growth in B-cell malignancies.
MeSH terms
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Animals
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Apoptosis / drug effects*
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Cyanoacrylates / pharmacology*
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Enzyme Inhibitors / pharmacology*
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Female
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Humans
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Lymphoma, Mantle-Cell / drug therapy*
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Male
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Multiple Myeloma / drug therapy*
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Pyridines / pharmacology*
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Ubiquitin Thiolesterase / antagonists & inhibitors*
Substances
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Cyanoacrylates
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Enzyme Inhibitors
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Pyridines
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Ubiquitin Thiolesterase