Abstract
The synthesis of pyrrole analogues of the analgesic drug lefetamine is reported. These derivatives bear the 1-phenyl-2-(1H-pyrrol-1-yl)ethylamino moiety. Compounds were evaluated for analgesic activities in mice by the hot plate and Randall-Selitto tests. Antiinflammatory activity was tested by the carrageenan-induced rat paw edema method. General neuropsychopharmacological effects were also screened. The most interesting compound, N,N-dimethyl-1-phenyl-2-(1H-pyrrol-1-yl)ethylamine, showed an analgesic effect comparable to that of lefetamine, but devoid of the neurotoxicity of this drug.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
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Anticonvulsants / chemical synthesis
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Chemical Phenomena
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Chemistry
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Exploratory Behavior / drug effects
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Female
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Male
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Mice
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Motor Activity / drug effects
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Muscle Relaxants, Central / chemical synthesis
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Phenethylamines / chemical synthesis
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Phenethylamines / pharmacology*
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Psychomotor Performance / drug effects
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Rats
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Rats, Inbred Strains
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Reaction Time / drug effects
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Anticonvulsants
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Muscle Relaxants, Central
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Phenethylamines
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lephetamine