Synthesis and antiviral evaluation of 6-p-ethylphenyl-5H-pyrrolo [3,4-b]pyridine-5,7-dione

Farmaco. 1989 Sep;44(9):893-6.

Abstract

The synthesis of 6-(p-ethylphenyl)-5H-pyrrolo [3,4-b]pyridine-5,7-dione is described. The compound has been studied for its in vitro activity on RNA-containing influenza viruses types A and B. The preliminary results indicate that the compound has a significant antiviral activity against influenza viruses types A and B at concentrations at which no cytotoxic effects on MRC-5 cells in tissue culture are present.

MeSH terms

  • Antiviral Agents / chemical synthesis*
  • Cell Survival / drug effects
  • Cells, Cultured
  • Influenza A virus / drug effects
  • Influenza B virus / drug effects
  • Pyridines / chemical synthesis*
  • Pyridines / pharmacology
  • Pyrrolidinones / chemical synthesis*
  • Pyrrolidinones / pharmacology

Substances

  • Antiviral Agents
  • Pyridines
  • Pyrrolidinones
  • 6-(4-ethylphenyl)-5H-pyrrolo(3,4-b)pyridine-5,7-dione