Rhodium(III)-Catalyzed Oxidative Annulation of 7-Azaindoles and Alkynes via Double C-H Activation

Org Lett. 2015 Jun 19;17(12):3018-21. doi: 10.1021/acs.orglett.5b01228. Epub 2015 Jun 8.

Abstract

Rhodium(III)-catalyzed double C-H activation involving N-directed ortho C-H activation and subsequent roll-over C-H activation of the heterocycle ring has been developed to form complex 7-azaindole derivatives in moderate to excellent yields. A broad scope of 7-azaindoles and internal alkynes has been demonstrated in this oxidative annulation reaction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry*
  • Azides / chemical synthesis*
  • Azides / chemistry*
  • Catalysis
  • Hydrogen Bonding
  • Molecular Structure
  • Oxidation-Reduction
  • Rhodium / chemistry*

Substances

  • Alkynes
  • Azides
  • 5-azidoindole
  • Rhodium