Dendritic cells change IL-27 production pattern during childhood

BMC Res Notes. 2015 Jun 9:8:232. doi: 10.1186/s13104-015-1182-0.

Abstract

Background: Interleukin-27 (IL-27) has been described to be highly expressed during the very first days after birth, but secretion of IL-27 by dendritic cells during the course of childhood has not been described.

Findings: In our present study we enrolled children (n = 55) in the range from 1 day of to 18 years of age and asked for a small whole blood sample. The capacity of dendritic cells to produce IL-27 during childhood was measured after whole blood culture with or without inflammatory stimuli. Results support recent findings of high IL-27 levels after birth and lowest levels in adults. Interestingly, we detected an interim peak production level at early adolescence.

Conclusion: These data hint to prominent roles of IL-27 at the very start of post-natal life. Furthermore, a link has been given to so far not described immunological events during puberty.

MeSH terms

  • Adolescent
  • Age Factors
  • Aging / immunology*
  • Child
  • Child, Preschool
  • Dendritic Cells / cytology
  • Dendritic Cells / drug effects
  • Dendritic Cells / immunology*
  • Dendritic Cells / metabolism
  • Female
  • Gene Expression Regulation, Developmental / immunology*
  • Humans
  • Infant
  • Infant, Newborn
  • Interferon-gamma / pharmacology
  • Interleukins / blood
  • Interleukins / genetics*
  • Interleukins / immunology
  • Lipopolysaccharides / pharmacology
  • Male
  • Poly I-C / pharmacology
  • Primary Cell Culture
  • Puberty / immunology

Substances

  • Interleukins
  • Lipopolysaccharides
  • MYDGF protein, human
  • Interferon-gamma
  • Poly I-C