Application of circulating tumor cells scope technique on circulating tumor cell research

Dawei Yang; Lijie Wang; Xiaochen Tian

doi:10.1186/2052-8426-2-8

Application of circulating tumor cells scope technique on circulating tumor cell research

Mol Cell Ther. 2014 Mar 10:2:8. doi: 10.1186/2052-8426-2-8. eCollection 2014.

Authors

Dawei Yang¹, Lijie Wang², Xiaochen Tian³

Affiliations

¹ Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, No. 180 Fenglin Rd, Shanghai, 200032 China.
² Department of Health Service Management, Second Military Medical University, No. 800 Xiangyin Rd, Shanghai, 200433 China.
³ China Key Laboratory of Medical Molecular Virology, Shanghai Medical College, Fudan University, No. 138 Yixueyuan Rd, Shanghai, 200032 China.

Abstract

Circulating tumor cells (CTCs) are becoming promising biomarkers in several cancers, such as colon, prostate, and breast carcinomas. Independent research groups have reported a correlation between CTC numbers and patient prognosis. Even more, the development of personalized medicine gives physicians impetus to utilize the advancement of molecular characterization of CTCs. This review introduces a new technique, CTCscope, and compares it with the current methods of CTCs detection, with particular emphasis on cancer research, and discusses the future application of this new method from bench to bed-side.

Keywords: CTCs; CTCscope; ISH; qRT-PCR.

Publication types

Review