Abstract
The promise of hybrid antimalarial agents and the precedence set by the antimalarial drug ferroquine prompted us to design ferrocene-pyrimidine conjugates. Herein, we report the synthesis, electrochemistry and anti-plasmodial evaluation of ferrocenyl-pyrimidine conjugates against chloroquine susceptible NF54 strain of the malaria parasite Plasmodium falciparum. Also their physicochemical properties have been studied.
Keywords:
Antiplasmodial studies; Ferrocene conjugates; Ferrocene/ferrocenium redox couple; Huisgen 1,3-dipolar cycloaddition; Lipophilicity.
Copyright © 2015 Elsevier Masson SAS. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antimalarials / chemical synthesis
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Antimalarials / chemistry*
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Antimalarials / pharmacology*
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Dose-Response Relationship, Drug
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Electrochemical Techniques*
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Ferrous Compounds / chemistry
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Ferrous Compounds / pharmacology*
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Malaria, Falciparum / drug therapy*
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Malaria, Falciparum / parasitology
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Metallocenes
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Molecular Structure
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Parasitic Sensitivity Tests
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Plasmodium falciparum / drug effects*
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Pyrimidines / chemistry
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Pyrimidines / pharmacology*
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Structure-Activity Relationship
Substances
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Antimalarials
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Ferrous Compounds
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Metallocenes
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Pyrimidines
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pyrimidine
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ferrocene