T-ALL: Home Is where the CXCL12 Is

Charles E de Bock; Jan Cools

doi:10.1016/j.ccell.2015.05.011

T-ALL: Home Is where the CXCL12 Is

Cancer Cell. 2015 Jun 8;27(6):745-6. doi: 10.1016/j.ccell.2015.05.011.

Authors

Charles E de Bock¹, Jan Cools²

Affiliations

¹ VIB Center for the Biology of Disease, KU Leuven, 3000 Leuven, Belgium; KU Leuven Center for Human Genetics, 3000 Leuven, Belgium. Electronic address: [email protected].
² VIB Center for the Biology of Disease, KU Leuven, 3000 Leuven, Belgium; KU Leuven Center for Human Genetics, 3000 Leuven, Belgium. Electronic address: [email protected].

PMID: 26058071
DOI: 10.1016/j.ccell.2015.05.011

Abstract

T cell acute lymphoblastic leukemia (T-ALL) is caused by mutations affecting cell survival, proliferation, and differentiation. In addition to requiring these mutations, Passaro and colleagues and Pitt and colleagues in this issue of Cancer Cell demonstrate that T-ALL initiating cells residing in bone marrow depend on the CXCR4/CXCL12 signaling axis for disease maintenance and progression.

Publication types

Comment

MeSH terms

Animals
Chemokine CXCL12 / antagonists & inhibitors*
Chemokine CXCL12 / biosynthesis*
Endothelium, Vascular / metabolism*
Female
Humans
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / metabolism*
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / pathology*
Pyridines / pharmacology*
Receptors, CXCR4 / metabolism*

Substances

Chemokine CXCL12
Pyridines
Receptors, CXCR4