MAPK8-mediated stabilization of SP1 is essential for RUNX1-RUNX1T1 - driven leukaemia

Br J Haematol. 2016 Mar;172(5):807-10. doi: 10.1111/bjh.13536. Epub 2015 Jun 8.
No abstract available

Keywords: CDKN1A; MAPK8/JNK1; RUNX1/RUNX1T1; SP1; myeloid leukaemia.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Core Binding Factor Alpha 2 Subunit / physiology*
  • Humans
  • Leukemia, Myeloid, Acute / metabolism*
  • Mitogen-Activated Protein Kinase 8 / physiology*
  • Oncogene Proteins, Fusion / physiology*
  • RUNX1 Translocation Partner 1 Protein
  • Sp1 Transcription Factor / metabolism*

Substances

  • AML1-ETO fusion protein, human
  • Core Binding Factor Alpha 2 Subunit
  • Oncogene Proteins, Fusion
  • RUNX1 Translocation Partner 1 Protein
  • Sp1 Transcription Factor
  • SP1 protein, human
  • Mitogen-Activated Protein Kinase 8